Human SNP ID | rs174578 |
---|---|
Human chromosome | chr11 |
Human SNP position | 61838027 |
Pig chromosome | chr2 |
Pig SNP position | 9129252 |
PubMed ID | 24816252 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24816252 |
Study | An atlas of genetic influences on human blood metabolites. |
Disease/Trait | Blood metabolite levels |
Initial sample | 7,824 European ancestry individuals |
Replication sample | NA |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61838027 |
Reported gene | FADS1 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174578-A |
SNPs | rs174578 |
Merged | 0 |
SNP id current | 174578 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.34 |
P value | 6E-42 |
Pvalue mlog | 41.2218487496163 |
P value text | (1-arachidonoylglycerophosphoethanolamine) |
Or beta | 0.035 |
%95 Ci | [0.029-0.041] unit decrease |
Platform | Affymetrix, Illumina [2100000] (imputed) |
CNV | N |
Mapped trait | blood metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005664 |
Study accession | GCST002443 |
PubMed ID | 24816252 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24816252 |
Study | An atlas of genetic influences on human blood metabolites. |
Disease/Trait | Blood metabolite levels |
Initial sample | 7,824 European ancestry individuals |
Replication sample | NA |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61838027 |
Reported gene | FADS1 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174578-A |
SNPs | rs174578 |
Merged | 0 |
SNP id current | 174578 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.34 |
P value | 3E-24 |
Pvalue mlog | 23.5228787452803 |
P value text | (1-arachidonoylglycerophosphoinositol) |
Or beta | 0.027 |
%95 Ci | [0.021-0.033] unit decrease |
Platform | Affymetrix, Illumina [2100000] (imputed) |
CNV | N |
Mapped trait | blood metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005664 |
Study accession | GCST002443 |
PubMed ID | 26584805 |
Journal | Genes Nutr |
Link | www.ncbi.nlm.nih.gov/pubmed/26584805 |
Study | A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population. |
Disease/Trait | Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) |
Initial sample | 717 Singaporean Chinese ancestry myocardial infarction cases, 644 Singaporean Chinese ancestry controls |
Replication sample | NA |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61838027 |
Reported gene | NR |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174578-T |
SNPs | rs174578 |
Merged | 0 |
SNP id current | 174578 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3353 |
P value | 0.0000000000000002 |
Pvalue mlog | 15.698970004336 |
P value text | |
Or beta | 0.0475 |
%95 Ci | [0.037-0.058] unit decrease |
Platform | Illumina [up to 1980188] (imputed) |
CNV | N |
Mapped trait | linoleic acid measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006807 |
Study accession | GCST003239 |
PubMed ID | 26068415 |
Journal | Nat Commun |
Link | www.ncbi.nlm.nih.gov/pubmed/26068415 |
Study | Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. |
Disease/Trait | Glycerophospholipid levels |
Initial sample | up to 7,478 European ancestry individuals |
Replication sample | 1,182 European ancestry individuals |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61838027 |
Reported gene | FADS2, FADS1, FADS3 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174578-A |
SNPs | rs174578 |
Merged | 0 |
SNP id current | 174578 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3267 |
P value | 0.000000000000000003 |
Pvalue mlog | 17.5228787452803 |
P value text | (Phosphatidylcholine diacyl C32:0) |
Or beta | 0.0362 |
%95 Ci | [0.028-0.044] unit decrease |
Platform | Affymetrix, Illumina [at least 296619] (imputed) |
CNV | N |
Mapped trait | glycerophospholipid measurement, blood metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0007630, http://www.ebi.ac.uk/efo/EFO_0005664 |
Study accession | GCST002965 |
PubMed ID | 26068415 |
Journal | Nat Commun |
Link | www.ncbi.nlm.nih.gov/pubmed/26068415 |
Study | Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. |
Disease/Trait | Glycerophospholipid levels |
Initial sample | up to 7,478 European ancestry individuals |
Replication sample | 1,182 European ancestry individuals |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61838027 |
Reported gene | FADS2, FADS1, FADS3 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174578-A |
SNPs | rs174578 |
Merged | 0 |
SNP id current | 174578 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3281 |
P value | 2E-43 |
Pvalue mlog | 42.698970004336 |
P value text | (Phosphatidylcholine diacyl C40:5) |
Or beta | 0.075 |
%95 Ci | [0.064-0.086] unit decrease |
Platform | Affymetrix, Illumina [at least 296619] (imputed) |
CNV | N |
Mapped trait | glycerophospholipid measurement, blood metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0007630, http://www.ebi.ac.uk/efo/EFO_0005664 |
Study accession | GCST002965 |
PubMed ID | 25646338 |
Journal | Am J Clin Nutr |
Link | www.ncbi.nlm.nih.gov/pubmed/25646338 |
Study | Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. |
Disease/Trait | Trans fatty acid levels |
Initial sample | 8,013 European ancestry individuals |
Replication sample | 1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61838027 |
Reported gene | NR |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174578-A |
SNPs | rs174578 |
Merged | 0 |
SNP id current | 174578 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3447 |
P value | 0.00000000000005 |
Pvalue mlog | 13.3010299956639 |
P value text | (Cis/trans-18:2, EA) |
Or beta | 0.0032 |
%95 Ci | [0.0024-0.004] unit increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | cis/trans-18:2 fatty acid measurement, trans fatty acid measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821 |
Study accession | GCST002721 |