SNP Detail For rs174578
1.Mapping Information
Human SNP ID rs174578
Human chromosome chr11
Human SNP position 61838027
Pig chromosome chr2
Pig SNP position 9129252
2.Annotation Information
PubMed ID24816252
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24816252
StudyAn atlas of genetic influences on human blood metabolites.
Disease/TraitBlood metabolite levels
Initial sample7,824 European ancestry individuals
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61838027
Reported geneFADS1
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers174578-A
SNPsrs174578
Merged0
SNP id current174578
Contextintron_variant
Intergenic0
Allele frequency0.34
P value6E-42
Pvalue mlog41.2218487496163
P value text(1-arachidonoylglycerophosphoethanolamine)
Or beta0.035
%95 Ci[0.029-0.041] unit decrease
PlatformAffymetrix, Illumina [2100000] (imputed)
CNVN
Mapped traitblood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002443
PubMed ID24816252
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24816252
StudyAn atlas of genetic influences on human blood metabolites.
Disease/TraitBlood metabolite levels
Initial sample7,824 European ancestry individuals
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61838027
Reported geneFADS1
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers174578-A
SNPsrs174578
Merged0
SNP id current174578
Contextintron_variant
Intergenic0
Allele frequency0.34
P value3E-24
Pvalue mlog23.5228787452803
P value text(1-arachidonoylglycerophosphoinositol)
Or beta0.027
%95 Ci[0.021-0.033] unit decrease
PlatformAffymetrix, Illumina [2100000] (imputed)
CNVN
Mapped traitblood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002443
PubMed ID26584805
JournalGenes Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/26584805
StudyA genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.
Disease/TraitPlasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
Initial sample717 Singaporean Chinese ancestry myocardial infarction cases, 644 Singaporean Chinese ancestry controls
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61838027
Reported geneNR
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers174578-T
SNPsrs174578
Merged0
SNP id current174578
Contextintron_variant
Intergenic0
Allele frequency0.3353
P value0.0000000000000002
Pvalue mlog15.698970004336
P value text
Or beta0.0475
%95 Ci[0.037-0.058] unit decrease
PlatformIllumina [up to 1980188] (imputed)
CNVN
Mapped traitlinoleic acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006807
Study accessionGCST003239
PubMed ID26068415
JournalNat Commun
Linkwww.ncbi.nlm.nih.gov/pubmed/26068415
StudyGenome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Disease/TraitGlycerophospholipid levels
Initial sampleup to 7,478 European ancestry individuals
Replication sample1,182 European ancestry individuals
Region11q12.2
Chromosome idchr11
Chromosome position61838027
Reported geneFADS2, FADS1, FADS3
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers174578-A
SNPsrs174578
Merged0
SNP id current174578
Contextintron_variant
Intergenic0
Allele frequency0.3267
P value0.000000000000000003
Pvalue mlog17.5228787452803
P value text(Phosphatidylcholine diacyl C32:0)
Or beta0.0362
%95 Ci[0.028-0.044] unit decrease
PlatformAffymetrix, Illumina [at least 296619] (imputed)
CNVN
Mapped traitglycerophospholipid measurement, blood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0007630, http://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002965
PubMed ID26068415
JournalNat Commun
Linkwww.ncbi.nlm.nih.gov/pubmed/26068415
StudyGenome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Disease/TraitGlycerophospholipid levels
Initial sampleup to 7,478 European ancestry individuals
Replication sample1,182 European ancestry individuals
Region11q12.2
Chromosome idchr11
Chromosome position61838027
Reported geneFADS2, FADS1, FADS3
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers174578-A
SNPsrs174578
Merged0
SNP id current174578
Contextintron_variant
Intergenic0
Allele frequency0.3281
P value2E-43
Pvalue mlog42.698970004336
P value text(Phosphatidylcholine diacyl C40:5)
Or beta0.075
%95 Ci[0.064-0.086] unit decrease
PlatformAffymetrix, Illumina [at least 296619] (imputed)
CNVN
Mapped traitglycerophospholipid measurement, blood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0007630, http://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002965
PubMed ID25646338
JournalAm J Clin Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/25646338
StudyGenetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
Disease/TraitTrans fatty acid levels
Initial sample8,013 European ancestry individuals
Replication sample1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
Region11q12.2
Chromosome idchr11
Chromosome position61838027
Reported geneNR
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers174578-A
SNPsrs174578
Merged0
SNP id current174578
Contextintron_variant
Intergenic0
Allele frequency0.3447
P value0.00000000000005
Pvalue mlog13.3010299956639
P value text(Cis/trans-18:2, EA)
Or beta0.0032
%95 Ci[0.0024-0.004] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitcis/trans-18:2 fatty acid measurement, trans fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821
Study accessionGCST002721