Human SNP ID | rs174570 |
---|---|
Human chromosome | chr11 |
Human SNP position | 61829740 |
Pig chromosome | chr2 |
Pig SNP position | 9120847 |
PubMed ID | 19060911 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060911 |
Study | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. |
Disease/Trait | Cholesterol, total |
Initial sample | 21,848 European ancestry individuals, 714 Orcadian individuals |
Replication sample | NA |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61829740 |
Reported gene | FADS2, FADS3 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174570-G |
SNPs | rs174570 |
Merged | 0 |
SNP id current | 174570 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.83 |
P value | 0.0000000002 |
Pvalue mlog | 9.69897000433601 |
P value text | |
Or beta | 0.09 |
%95 Ci | [NR] s.d. increase |
Platform | Affymetrix, Illumina [up to 600000] |
CNV | N |
Mapped trait | total cholesterol measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004574 |
Study accession | GCST000285 |
PubMed ID | 19060911 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060911 |
Study | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. |
Disease/Trait | LDL cholesterol |
Initial sample | 17,083 European ancestry individuals, 714 Orcadian individuals |
Replication sample | NA |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61829740 |
Reported gene | FADS2, FADS3 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174570-G |
SNPs | rs174570 |
Merged | 0 |
SNP id current | 174570 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.83 |
P value | 0.0000000000004 |
Pvalue mlog | 12.397940008672 |
P value text | |
Or beta | 0.11 |
%95 Ci | [NR] s.d. increase |
Platform | Affymetrix, Illumina [up to 600000] |
CNV | N |
Mapped trait | low density lipoprotein cholesterol measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004611 |
Study accession | GCST000282 |
PubMed ID | 19060911 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060911 |
Study | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. |
Disease/Trait | HDL cholesterol |
Initial sample | 20,697 European ancestry individuals, 715 Orcadian individuals |
Replication sample | NA |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61829740 |
Reported gene | FADS2, FADS3 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174570-G |
SNPs | rs174570 |
Merged | 0 |
SNP id current | 174570 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.83 |
P value | 0.000004 |
Pvalue mlog | 5.39794000867203 |
P value text | |
Or beta | 0.06 |
%95 Ci | [NR] s.d. increase |
Platform | Affymetrix, Illumina [up to 600000] |
CNV | N |
Mapped trait | high density lipoprotein cholesterol measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004612 |
Study accession | GCST000288 |
PubMed ID | 24647736 |
Journal | Diabetes |
Link | www.ncbi.nlm.nih.gov/pubmed/24647736 |
Study | Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. |
Disease/Trait | Glycated hemoglobin levels |
Initial sample | 17,290 East Asian ancestry individuals, 1,727 Malay ancestry individuals |
Replication sample | up to 13,585 East Asian ancestry individuals |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61829740 |
Reported gene | FADS2 |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174570-C |
SNPs | rs174570 |
Merged | 0 |
SNP id current | 174570 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.55 |
P value | 0.0000002 |
Pvalue mlog | 6.69897000433601 |
P value text | |
Or beta | 0.04 |
%95 Ci | [0.020-0.060] unit increase |
Platform | Affymetrix, Illumina [up to 2400000] (imputed) |
CNV | N |
Mapped trait | A1C measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004541 |
Study accession | GCST002390 |
PubMed ID | 25646338 |
Journal | Am J Clin Nutr |
Link | www.ncbi.nlm.nih.gov/pubmed/25646338 |
Study | Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. |
Disease/Trait | Trans fatty acid levels |
Initial sample | 8,013 European ancestry individuals |
Replication sample | 1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals |
Region | 11q12.2 |
Chromosome id | chr11 |
Chromosome position | 61829740 |
Reported gene | NR |
Mapped gene | FADS2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 9415 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs174570-T |
SNPs | rs174570 |
Merged | 0 |
SNP id current | 174570 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.1353 |
P value | 0.0000001 |
Pvalue mlog | 7 |
P value text | (Cis/trans-18:2, EA) |
Or beta | 0.0032 |
%95 Ci | [0.002-0.0044] unit increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | cis/trans-18:2 fatty acid measurement, trans fatty acid measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821 |
Study accession | GCST002721 |