SNP Detail For rs174556
1.Mapping Information
Human SNP ID rs174556
Human chromosome chr11
Human SNP position 61813163
Pig chromosome chr2
Pig SNP position 9260345
2.Annotation Information
PubMed ID24816252
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24816252
StudyAn atlas of genetic influences on human blood metabolites.
Disease/TraitBlood metabolite levels
Initial sample7,824 European ancestry individuals
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61813163
Reported geneFADS1
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174556-T
SNPsrs174556
Merged0
SNP id current174556
Contextintron_variant
Intergenic0
Allele frequency0.3
P value2E-22
Pvalue mlog21.698970004336
P value text(eicosapentaenoate (EPA; 20:5n3))
Or beta0.036
%95 Ci[0.028-0.044] unit decrease
PlatformAffymetrix, Illumina [2100000] (imputed)
CNVN
Mapped traitblood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002443
PubMed ID25646338
JournalAm J Clin Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/25646338
StudyGenetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
Disease/TraitTrans fatty acid levels
Initial sample8,013 European ancestry individuals
Replication sample1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
Region11q12.2
Chromosome idchr11
Chromosome position61813163
Reported geneNR
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174556-T
SNPsrs174556
Merged0
SNP id current174556
Contextintron_variant
Intergenic0
Allele frequency0.294
P value0.00000000000003
Pvalue mlog13.5228787452803
P value text(Cis/trans-18:2, EA)
Or beta0.0033
%95 Ci[0.0025-0.0041] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitcis/trans-18:2 fatty acid measurement, trans fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821
Study accessionGCST002721