SNP Detail For rs174555
1.Mapping Information
Human SNP ID rs174555
Human chromosome chr11
Human SNP position 61812288
Pig chromosome chr2
Pig SNP position 9259318
2.Annotation Information
PubMed ID24823311
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24823311
StudyGenome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Disease/TraitPlasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid)
Initial sample8,631 European ancestry individuals
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61812288
Reported geneFTH1, C11orf9, FADS1, DAGLA, FADS2, FEN1, C11orf10, FADS3, RAB3IL1, BEST1
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174555-T
SNPsrs174555
Merged0
SNP id current174555
Contextintron_variant
Intergenic0
Allele frequency0.71
P value5E-168
Pvalue mlog167.301029995663
P value text
Or beta0.39
%95 Ci[NR] unit decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitomega-6 polyunsaturated fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005680
Study accessionGCST002444
PubMed ID26068415
JournalNat Commun
Linkwww.ncbi.nlm.nih.gov/pubmed/26068415
StudyGenome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Disease/TraitGlycerophospholipid levels
Initial sampleup to 7,478 European ancestry individuals
Replication sample1,182 European ancestry individuals
Region11q12.2
Chromosome idchr11
Chromosome position61812288
Reported geneFADS1, FADS2, FADS3
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174555-T
SNPsrs174555
Merged0
SNP id current174555
Contextintron_variant
Intergenic0
Allele frequency0.713
P value1E-35
Pvalue mlog35
P value text(Phosphatidylcholine diacyl C36:3)
Or beta0.0553
%95 Ci[0.047-0.064] unit decrease
PlatformAffymetrix, Illumina [at least 296619] (imputed)
CNVN
Mapped traitglycerophospholipid measurement, blood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0007630, http://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002965
PubMed ID25646338
JournalAm J Clin Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/25646338
StudyGenetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
Disease/TraitTrans fatty acid levels
Initial sample8,013 European ancestry individuals
Replication sample1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
Region11q12.2
Chromosome idchr11
Chromosome position61812288
Reported geneNR
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174555-T
SNPsrs174555
Merged0
SNP id current174555
Contextintron_variant
Intergenic0
Allele frequency0.7057
P value0.000000000000006
Pvalue mlog14.2218487496163
P value text(Cis/trans-18:2, EA)
Or beta0.0034
%95 Ci[0.0026-0.0042] unit decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitcis/trans-18:2 fatty acid measurement, trans fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821
Study accessionGCST002721