SNP Detail For rs174545
1.Mapping Information
Human SNP ID rs174545
Human chromosome chr11
Human SNP position 61801834
Pig chromosome chr2
Pig SNP position 9250333
2.Annotation Information
PubMed ID26584805
JournalGenes Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/26584805
StudyA genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.
Disease/TraitDelta-6 desaturase activity
Initial sample717 Singaporean Chinese ancestry myocardial infarction cases, 644 Singaporean Chinese ancestry controls
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61801834
Reported geneNR
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174545-G
SNPsrs174545
Merged0
SNP id current174545
Context3_prime_UTR_variant
Intergenic0
Allele frequency0.6561
P value5E-37
Pvalue mlog36.3010299956639
P value text
Or beta0.2367
%95 Ci[0.20-0.27] unit decrease
PlatformIllumina [up to 1980188] (imputed)
CNVN
Mapped trait
Mapped trait URI
Study accessionGCST003244
PubMed ID25646338
JournalAm J Clin Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/25646338
StudyGenetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
Disease/TraitTrans fatty acid levels
Initial sample8,013 European ancestry individuals
Replication sample1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
Region11q12.2
Chromosome idchr11
Chromosome position61801834
Reported geneNR
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174545-C
SNPsrs174545
Merged0
SNP id current174545
Context3_prime_UTR_variant
Intergenic0
Allele frequency0.6702
P value0.00000000000007
Pvalue mlog13.1549019599857
P value text(Cis/trans-18:2, EA)
Or beta0.0031
%95 Ci[0.0023-0.0039] unit decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitcis/trans-18:2 fatty acid measurement, trans fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821
Study accessionGCST002721
PubMed ID25500335
JournalProstaglandins Leukot Essent Fatty Acids
Linkwww.ncbi.nlm.nih.gov/pubmed/25500335
StudyA genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.
Disease/TraitRed blood cell fatty acid levels
Initial sample2,633 individuals
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61801834
Reported geneFADS1, C11orf10, C11orf9, FADS2, FEN1, FADS3, RAB3IL1
Mapped geneFADS1
Upstream gene id
Downstream gene id
SNP gene ids3992
Upstream gene distance
Downstream gene distance
SNP risk allelers174545-?
SNPsrs174545
Merged0
SNP id current174545
Context3_prime_UTR_variant
Intergenic0
Allele frequency0.33
P value8E-90
Pvalue mlog89.096910013008
P value text(AA)
Or beta0.374
%95 Ci[NR] unit decrease
PlatformAffymetrix [~ 2500000] (imputed)
CNVN
Mapped traitarachidonic acid measurement, fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006808, http://www.ebi.ac.uk/efo/EFO_0005110
Study accessionGCST002712