SNP Detail For rs17389644
1.Mapping Information
Human SNP ID rs17389644
Human chromosome chr4
Human SNP position 122576542
Pig chromosome chr8
Pig SNP position 108728657
2.Annotation Information
PubMed ID25574825
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25574825
StudyGenome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
Disease/TraitAtopic dermatitis
Initial sample2,079 European ancestry cases, 3,867 European ancestry controls
Replication sampleNA
Region4q27
Chromosome idchr4
Chromosome position122576542
Reported geneIL2, IL21
Mapped geneIL2 - IL21
Upstream gene id3558
Downstream gene id59067
SNP gene ids
Upstream gene distance120047
Downstream gene distance36086
SNP risk allelers17389644-A
SNPsrs17389644
Merged0
SNP id current17389644
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.000001
Pvalue mlog6
P value text
Or beta1.208
%95 Ci[1.119鈥?.304]
PlatformAffymetrix, Illumina, Perlegen [up to 5493100] (imputed)
CNVN
Mapped traitatopic eczema
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000274
Study accessionGCST002737
PubMed ID26482879
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26482879
StudyMulti-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Disease/TraitAtopic dermatitis
Initial sample18,900 European ancestry cases, 1,472 Japanese ancestry cases, 422 African American cases, 300 Latino cases, 305 cases, 84,166 European ancestry controls, 7,966 Japanese ancestry controls, 844 African American controls, 1,592 Latino controls, 896 controls
Replication sample30,588 European ancestry cases, 459 African American cases, 1,012 Chinese ancestry cases, 226,537 European ancestry controls, 729 African American controls, 1,362 Chinese ancestry controls
Region4q27
Chromosome idchr4
Chromosome position122576542
Reported geneIL2, IL21
Mapped geneIL2 - IL21
Upstream gene id3558
Downstream gene id59067
SNP gene ids
Upstream gene distance120047
Downstream gene distance36086
SNP risk allelers17389644-A
SNPsrs17389644
Merged0
SNP id current17389644
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.000004
Pvalue mlog5.39794000867203
P value text(EA, fixed effects)
Or beta1.07
%95 Ci[1.04-1.10]
PlatformIllumina [15539996] (imputed)
CNVN
Mapped traitatopic eczema
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000274
Study accessionGCST003184