SNP Detail For rs1733724
1.Mapping Information
Human SNP ID rs1733724
Human chromosome chr10
Human SNP position 52464217
Pig chromosome chr14
Pig SNP position 105890432
2.Annotation Information
PubMed ID21076409
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21076409
StudyCommon variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
Disease/TraitQRS duration
Initial sample39,717 European ancestry individuals, 690 Orcadian individuals
Replication sample7,170 European ancestry individuals
Region10q21.1
Chromosome idchr10
Chromosome position52464217
Reported geneDKK1
Mapped geneLINC01468
Upstream gene id
Downstream gene id
SNP gene ids101928687
Upstream gene distance
Downstream gene distance
SNP risk allelers1733724-A
SNPsrs1733724
Merged0
SNP id current1733724
Contextintron_variant
Intergenic0
Allele frequency0.25
P value0.00000003
Pvalue mlog7.52287874528033
P value text
Or beta0.49
%95 Ci[0.31-0.67] ms increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitheart function measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004311
Study accessionGCST000872
PubMed ID20062063
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20062063
StudySeveral common variants modulate heart rate, PR interval and QRS duration.
Disease/TraitElectrocardiographic traits
Initial sampleUp to 12,670 European ancestry individuals
Replication sampleUp to 10,352 European ancestry individuals
Region10q21.1
Chromosome idchr10
Chromosome position52464217
Reported geneDKK1
Mapped geneLINC01468
Upstream gene id
Downstream gene id
SNP gene ids101928687
Upstream gene distance
Downstream gene distance
SNP risk allelers1733724-T
SNPsrs1733724
Merged0
SNP id current1733724
Contextintron_variant
Intergenic0
Allele frequency0.21
P value0.00000007
Pvalue mlog7.15490195998574
P value text(QRS duration)
Or beta5.62
%95 Ci[3.58-7.66] % s.d. increase
PlatformIllumina [306060]
CNVN
Mapped traitQRS complex
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005054
Study accessionGCST000561