Human SNP ID | rs1733724 |
---|---|
Human chromosome | chr10 |
Human SNP position | 52464217 |
Pig chromosome | chr14 |
Pig SNP position | 105890432 |
PubMed ID | 21076409 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21076409 |
Study | Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. |
Disease/Trait | QRS duration |
Initial sample | 39,717 European ancestry individuals, 690 Orcadian individuals |
Replication sample | 7,170 European ancestry individuals |
Region | 10q21.1 |
Chromosome id | chr10 |
Chromosome position | 52464217 |
Reported gene | DKK1 |
Mapped gene | LINC01468 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 101928687 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1733724-A |
SNPs | rs1733724 |
Merged | 0 |
SNP id current | 1733724 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.25 |
P value | 0.00000003 |
Pvalue mlog | 7.52287874528033 |
P value text | |
Or beta | 0.49 |
%95 Ci | [0.31-0.67] ms increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | heart function measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004311 |
Study accession | GCST000872 |
PubMed ID | 20062063 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20062063 |
Study | Several common variants modulate heart rate, PR interval and QRS duration. |
Disease/Trait | Electrocardiographic traits |
Initial sample | Up to 12,670 European ancestry individuals |
Replication sample | Up to 10,352 European ancestry individuals |
Region | 10q21.1 |
Chromosome id | chr10 |
Chromosome position | 52464217 |
Reported gene | DKK1 |
Mapped gene | LINC01468 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 101928687 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1733724-T |
SNPs | rs1733724 |
Merged | 0 |
SNP id current | 1733724 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.21 |
P value | 0.00000007 |
Pvalue mlog | 7.15490195998574 |
P value text | (QRS duration) |
Or beta | 5.62 |
%95 Ci | [3.58-7.66] % s.d. increase |
Platform | Illumina [306060] |
CNV | N |
Mapped trait | QRS complex |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005054 |
Study accession | GCST000561 |