SNP Detail For rs17118552
1.Mapping Information
Human SNP ID rs17118552
Human chromosome chr14
Human SNP position 47405354
Pig chromosome chr1
Pig SNP position 197588006
2.Annotation Information
PubMed ID22491018
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/22491018
StudyGenome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
Disease/TraitResponse to tocilizumab in rheumatoid arthritis
Initial sample1,157 European and other ancestry rheumatoid arthritis cases
Replication sample526 European and other ancestry rheumatoid arthritis cases
Region14q21.3
Chromosome idchr14
Chromosome position47405354
Reported geneMDGA2
Mapped geneMDGA2
Upstream gene id
Downstream gene id
SNP gene ids161357
Upstream gene distance
Downstream gene distance
SNP risk allelers17118552-?
SNPsrs17118552
Merged0
SNP id current17118552
Contextintron_variant
Intergenic0
Allele frequency0.014
P value0.0000002
Pvalue mlog6.69897000433601
P value text(CTJC , EA, RF+)
Or beta17.19
%95 Ci[NR] unit increase
PlatformIllumina [534053]
CNVN
Mapped traitrheumatoid arthritis, response to drug
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685, http://purl.obolibrary.org/obo/GO_0042493
Study accessionGCST001476