Human SNP ID | rs16969968 |
---|---|
Human chromosome | chr15 |
Human SNP position | 78590583 |
Pig chromosome | chr7 |
Pig SNP position | 52780579 |
PubMed ID | 26634245 |
---|---|
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1 |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78590583 |
Reported gene | CHRNA5 |
Mapped gene | CHRNA5 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 1138 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs16969968-A |
SNPs | rs16969968 |
Merged | 0 |
SNP id current | 16969968 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.578 |
P value | 0.000000000000006 |
Pvalue mlog | 14.2218487496163 |
P value text | |
Or beta | 0.078 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume, response to bronchodilator |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366 |
Study accession | GCST003262 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio in COPD |
Initial sample | 5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78590583 |
Reported gene | CHRNA5 |
Mapped gene | CHRNA5 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 1138 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs16969968-A |
SNPs | rs16969968 |
Merged | 0 |
SNP id current | 16969968 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.503 |
P value | 0.0000004 |
Pvalue mlog | 6.39794000867203 |
P value text | |
Or beta | 0.012 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, chronic obstructive pulmonary disease, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0000341, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003265 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Pre bronchodilator FEV1 |
Initial sample | 6,659 European ancestry current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78590583 |
Reported gene | CHRNA5 |
Mapped gene | CHRNA5 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 1138 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs16969968NR |
SNPs | rs16969968 |
Merged | 0 |
SNP id current | 16969968 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000000002 |
Pvalue mlog | 8.69897000433601 |
P value text | |
Or beta | 0.07994 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314 |
Study accession | GCST003266 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Pre bronchodilator FEV1/FVC ratio |
Initial sample | 6,659 European ancestry current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78590583 |
Reported gene | CHRNA5 |
Mapped gene | CHRNA5 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 1138 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs16969968-? |
SNPs | rs16969968 |
Merged | 0 |
SNP id current | 16969968 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.0000000002 |
Pvalue mlog | 9.69897000433601 |
P value text | |
Or beta | 0.01709 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | FEV/FEC ratio |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003267 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78590583 |
Reported gene | CHRNA5 |
Mapped gene | CHRNA5 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 1138 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs16969968-A |
SNPs | rs16969968 |
Merged | 0 |
SNP id current | 16969968 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.578 |
P value | 0.000000000000001 |
Pvalue mlog | 15 |
P value text | |
Or beta | 0.017 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003264 |