SNP Detail For rs16938910
1.Mapping Information
Human SNP ID rs16938910
Human chromosome chr8
Human SNP position 74461713
Pig chromosome chr4
Pig SNP position 67295111
2.Annotation Information
PubMed ID22491018
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/22491018
StudyGenome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
Disease/TraitResponse to tocilizumab in rheumatoid arthritis
Initial sample1,157 European and other ancestry rheumatoid arthritis cases
Replication sample526 European and other ancestry rheumatoid arthritis cases
Region8q21.11
Chromosome idchr8
Chromosome position74461713
Reported geneintergenic
Mapped geneGDAP1 - MIR5681A
Upstream gene id54332
Downstream gene id100847058
SNP gene ids
Upstream gene distance94603
Downstream gene distance86830
SNP risk allelers16938910-?
SNPsrs16938910
Merged0
SNP id current16938910
Contextintron_variant
Intergenic1
Allele frequency0.011
P value0.0000004
Pvalue mlog6.39794000867203
P value text(CSJC , EA, RF+)
Or beta28.66
%95 Ci[NR] unit increase
PlatformIllumina [534053]
CNVN
Mapped traitrheumatoid arthritis, response to drug
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685, http://purl.obolibrary.org/obo/GO_0042493
Study accessionGCST001476