SNP Detail For rs16857031
1.Mapping Information
Human SNP ID rs16857031
Human chromosome chr1
Human SNP position 162143120
Pig chromosome chr4
Pig SNP position 96285316
2.Annotation Information
PubMed ID19305408
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19305408
StudyCommon variants at ten loci influence QT interval duration in the QTGEN Study.
Disease/TraitQT interval
Initial sample13,685 European ancestry individuals
Replication sample15,854 European ancestry individuals
Region1q23.3
Chromosome idchr1
Chromosome position162143120
Reported geneNOS1AP
Mapped geneNOS1AP, LOC105371475
Upstream gene id
Downstream gene id
SNP gene ids9722, 105371475
Upstream gene distance
Downstream gene distance
SNP risk allelers16857031-G
SNPsrs16857031
Merged0
SNP id current16857031
Contextintron_variant
Intergenic0
Allele frequency0.14
P value1E-34
Pvalue mlog34
P value text
Or beta2.63
%95 Ci[2.28-2.97] msec increase
PlatformAffymetrix, Illumina [up to 2543686] (imputed)
CNVN
Mapped traitQT interval
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004682
Study accessionGCST000363
PubMed ID24952745
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24952745
StudyGenetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
Disease/TraitQT interval
Initial sampleUp to 70,389 European ancestry individuals, up to 672 Orcadian individuals
Replication sampleUp to 33,316 European ancestry individuals
Region1q23.3
Chromosome idchr1
Chromosome position162143120
Reported geneNOS1AP
Mapped geneNOS1AP, LOC105371475
Upstream gene id
Downstream gene id
SNP gene ids9722, 105371475
Upstream gene distance
Downstream gene distance
SNP risk allelers16857031-G
SNPsrs16857031
Merged0
SNP id current16857031
Contextintron_variant
Intergenic0
Allele frequency0.132
P value7E-61
Pvalue mlog60.1549019599857
P value text
Or beta2.37
%95 Ci[2.1-2.64] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitQT interval
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004682
Study accessionGCST002500