SNP Detail For rs1669070
1.Mapping Information
Human SNP ID rs1669070
Human chromosome chr2
Human SNP position 231327593
Pig chromosome chr15
Pig SNP position 145773917
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region2q37.1
Chromosome idchr2
Chromosome position231327593
Reported geneHTR2B, NMUR1
Mapped geneARMC9
Upstream gene id
Downstream gene id
SNP gene ids80210
Upstream gene distance
Downstream gene distance
SNP risk allelers1669070-T
SNPsrs1669070
Merged0
SNP id current1669070
Contextintron_variant
Intergenic0
Allele frequency0.4
P value0.000004
Pvalue mlog5.39794000867203
P value text(EA-glucose response)
Or beta3.02
%95 Ci[1.73-4.31] mg/dL decrease
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, fasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST001859