SNP Detail For rs157582
1.Mapping Information
Human SNP ID rs157582
Human chromosome chr19
Human SNP position 44892962
Pig chromosome chr6
Pig SNP position 47258607
2.Annotation Information
PubMed ID22399527
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22399527
StudyGenome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
Disease/TraitMetabolic syndrome
Initial sample2,637 European ancestry cases, 7,927 European ancestry controls
Replication sampleNA
Region19q13.32
Chromosome idchr19
Chromosome position44892962
Reported geneAPOE, TOMM40
Mapped geneTOMM40
Upstream gene id
Downstream gene id
SNP gene ids10452
Upstream gene distance
Downstream gene distance
SNP risk allelers157582-T
SNPsrs157582
Merged0
SNP id current157582
Contextintron_variant
Intergenic0
Allele frequency0.22
P value0.00000001
Pvalue mlog8
P value text(TG)
Or beta0.1
%95 Ci[NR] mmol/l increase
PlatformIllumina [1257079] (imputed)
CNVN
Mapped traitmetabolic syndrome
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000195
Study accessionGCST001436
PubMed ID22005930
JournalMol Psychiatry
Linkwww.ncbi.nlm.nih.gov/pubmed/22005930
StudyGenome-wide association study of Alzheimer__s disease with psychotic symptoms.
Disease/TraitPsychosis and Alzheimer__s disease
Initial sample1,039 European ancestry cases with psychosis, 5,659 European ancestry controls, 260 European, African American and Native American ancestry cases with psychosis from 264 families
Replication sampleNA
Region19q13.32
Chromosome idchr19
Chromosome position44892962
Reported geneAPOE
Mapped geneTOMM40
Upstream gene id
Downstream gene id
SNP gene ids10452
Upstream gene distance
Downstream gene distance
SNP risk allelers157582-?
SNPsrs157582
Merged0
SNP id current157582
Contextintron_variant
Intergenic0
Allele frequency0.26
P value9E-52
Pvalue mlog51.0457574905606
P value text
Or beta2.3
%95 Ci[NR]
PlatformIllumina [1847262] (imputed)
CNVN
Mapped traitAlzheimers disease, psychotic symptoms
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249, http://www.ebi.ac.uk/efo/EFO_0005940
Study accessionGCST001285
PubMed ID26582766
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26582766
StudyGenetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese Populations.
Disease/TraitTriglycerides
Initial sample8,344 Han Chinese ancestry individuals
Replication sample14,739 Han Chinese ancestry individuals
Region19q13.32
Chromosome idchr19
Chromosome position44892962
Reported geneAPOE
Mapped geneTOMM40
Upstream gene id
Downstream gene id
SNP gene ids10452
Upstream gene distance
Downstream gene distance
SNP risk allelers157582-T
SNPsrs157582
Merged0
SNP id current157582
Contextintron_variant
Intergenic0
Allele frequency0.18
P value4E-22
Pvalue mlog21.397940008672
P value text
Or beta0.078
%95 Ci[0.062-0.094] unit increase
PlatformAffymetrix, Illumina [2573667] (imputed)
CNVN
Mapped traittriglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST003217
PubMed ID26421299
JournalBiomed Res Int
Linkwww.ncbi.nlm.nih.gov/pubmed/26421299
StudyGenetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.
Disease/TraitCingulate cortical amyloid beta load
Initial sample215 European ancestry early mild cognitive impairment cases, 152 European ancestry late mild cognitive impairment cases, 45 European ancestry Alzheimer disease cases, 190 European ancestry controls
Replication sampleNA
Region19q13.32
Chromosome idchr19
Chromosome position44892962
Reported geneTOMM40
Mapped geneTOMM40
Upstream gene id
Downstream gene id
SNP gene ids10452
Upstream gene distance
Downstream gene distance
SNP risk allelers157582 -?
SNPsrs157582
Merged0
SNP id current157582
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.0000000000000004
Pvalue mlog15.397940008672
P value text
Or beta
%95 Ci
PlatformIllumina [582718]
CNVN
Mapped traitamyloid-beta measurement, cingulate cortex measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005194, http://www.ebi.ac.uk/efo/EFO_0007738
Study accessionGCST003113