SNP Detail For rs1543922
1.Mapping Information
Human SNP ID rs1543922
Human chromosome chr19
Human SNP position 51581583
Pig chromosome chr6
Pig SNP position 51776032
2.Annotation Information
PubMed ID22491018
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/22491018
StudyGenome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
Disease/TraitResponse to tocilizumab in rheumatoid arthritis
Initial sample1,157 European and other ancestry rheumatoid arthritis cases
Replication sample526 European and other ancestry rheumatoid arthritis cases
Region19q13.41
Chromosome idchr19
Chromosome position51581583
Reported geneintergenic
Mapped geneZNF175
Upstream gene id
Downstream gene id
SNP gene ids7728
Upstream gene distance
Downstream gene distance
SNP risk allelers1543922-?
SNPsrs1543922
Merged0
SNP id current1543922
Contextintron_variant
Intergenic0
Allele frequency0.036
P value0.0000003
Pvalue mlog6.52287874528033
P value text(CSJC, EA, RF-)
Or beta34.48
%95 Ci[NR] unit increase
PlatformIllumina [534053]
CNVN
Mapped traitrheumatoid arthritis, response to drug
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685, http://purl.obolibrary.org/obo/GO_0042493
Study accessionGCST001476