SNP Detail For rs1516725
1.Mapping Information
Human SNP ID rs1516725
Human chromosome chr3
Human SNP position 186106215
Pig chromosome chr13
Pig SNP position 133378987
2.Annotation Information
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region3q27.2
Chromosome idchr3
Chromosome position186106215
Reported geneETV5
Mapped geneETV5
Upstream gene id
Downstream gene id
SNP gene ids2119
Upstream gene distance
Downstream gene distance
SNP risk allelers1516725-C
SNPsrs1516725
Merged0
SNP id current1516725
Contextintron_variant
Intergenic0
Allele frequency0.86
P value0.000000003
Pvalue mlog8.52287874528033
P value text(Obesity class II)
Or beta1.15
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitBody mass index
Initial sample7,962 European ancestry high body mass index individuals, 8,106 European ancestry low body mass index individuals
Replication sample4,900 European ancestry high body mass index individuals, 4,891 European ancestry low body mass index individuals
Region3q27.2
Chromosome idchr3
Chromosome position186106215
Reported geneETV5
Mapped geneETV5
Upstream gene id
Downstream gene id
SNP gene ids2119
Upstream gene distance
Downstream gene distance
SNP risk allelers1516725-C
SNPsrs1516725
Merged0
SNP id current1516725
Contextintron_variant
Intergenic0
Allele frequency0.86
P value0.00000004
Pvalue mlog7.39794000867203
P value text
Or beta1.21
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST001955
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region3q27.2
Chromosome idchr3
Chromosome position186106215
Reported geneETV5
Mapped geneETV5
Upstream gene id
Downstream gene id
SNP gene ids2119
Upstream gene distance
Downstream gene distance
SNP risk allelers1516725-C
SNPsrs1516725
Merged0
SNP id current1516725
Contextintron_variant
Intergenic0
Allele frequency0.873
P value0.000000000001
Pvalue mlog12
P value text(EA, men)
Or beta0.044
%95 Ci[0.032-0.056] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region3q27.2
Chromosome idchr3
Chromosome position186106215
Reported geneETV5
Mapped geneETV5
Upstream gene id
Downstream gene id
SNP gene ids2119
Upstream gene distance
Downstream gene distance
SNP risk allelers1516725-C
SNPsrs1516725
Merged0
SNP id current1516725
Contextintron_variant
Intergenic0
Allele frequency0.87
P value0.000000000000002
Pvalue mlog14.698970004336
P value text(EA, women)
Or beta0.047
%95 Ci[0.035-0.058] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region3q27.2
Chromosome idchr3
Chromosome position186106215
Reported geneETV5
Mapped geneETV5
Upstream gene id
Downstream gene id
SNP gene ids2119
Upstream gene distance
Downstream gene distance
SNP risk allelers1516725-C
SNPsrs1516725
Merged0
SNP id current1516725
Contextintron_variant
Intergenic0
Allele frequency0.872
P value2E-22
Pvalue mlog21.698970004336
P value text(EA)
Or beta0.045
%95 Ci[0.036-0.054] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region3q27.2
Chromosome idchr3
Chromosome position186106215
Reported geneETV5
Mapped geneETV5
Upstream gene id
Downstream gene id
SNP gene ids2119
Upstream gene distance
Downstream gene distance
SNP risk allelers1516725-C
SNPsrs1516725
Merged0
SNP id current1516725
Contextintron_variant
Intergenic0
Allele frequency0.869
P value1E-24
Pvalue mlog24
P value text
Or beta0.045
%95 Ci[0.036-0.053] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783