SNP Detail For rs1504550
1.Mapping Information
Human SNP ID rs1504550
Human chromosome chr15
Human SNP position 78473908
Pig chromosome chr7
Pig SNP position 52997590
2.Annotation Information
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78473908
Reported geneIREB2
Mapped geneIREB2
Upstream gene id
Downstream gene id
SNP gene ids3658
Upstream gene distance
Downstream gene distance
SNP risk allelers1504550-A
SNPsrs1504550
Merged0
SNP id current1504550
Context3_prime_UTR_variant
Intergenic0
Allele frequency0.663
P value0.0000000000001
Pvalue mlog13
P value text
Or beta0.075
%95 CiNR unit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitforced expiratory volume, response to bronchodilator
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366
Study accessionGCST003262
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio in COPD
Initial sample5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78473908
Reported geneIREB2
Mapped geneIREB2
Upstream gene id
Downstream gene id
SNP gene ids3658
Upstream gene distance
Downstream gene distance
SNP risk allelers1504550-A
SNPsrs1504550
Merged0
SNP id current1504550
Context3_prime_UTR_variant
Intergenic0
Allele frequency0.613
P value0.000002
Pvalue mlog5.69897000433601
P value text
Or beta0.012
%95 CiNR unit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, chronic obstructive pulmonary disease, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0000341, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003265
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78473908
Reported geneIREB2
Mapped geneIREB2
Upstream gene id
Downstream gene id
SNP gene ids3658
Upstream gene distance
Downstream gene distance
SNP risk allelers1504550-A
SNPsrs1504550
Merged0
SNP id current1504550
Context3_prime_UTR_variant
Intergenic0
Allele frequency0.666
P value0.0000000000008
Pvalue mlog12.096910013008
P value text
Or beta0.015
%95 Ciunit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003264