SNP Detail For rs1497406
1.Mapping Information
Human SNP ID rs1497406
Human chromosome chr1
Human SNP position 16178825
Pig chromosome chr6
Pig SNP position 69615742
2.Annotation Information
PubMed ID22001757
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22001757
StudyGenome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Disease/TraitLiver enzyme levels (gamma-glutamyl transferase)
Initial sampleUp to 52,350 European ancestry individuals, up to 8,739 Indian Asian ancestry individuals
Replication sampleNA
Region1p36.13
Chromosome idchr1
Chromosome position16178825
Reported geneEPHA2, RSG1
Mapped geneLOC101927479 - ARHGEF19
Upstream gene id101927479
Downstream gene id128272
SNP gene ids
Upstream gene distance10609
Downstream gene distance19031
SNP risk allelers1497406-G
SNPsrs1497406
Merged0
SNP id current1497406
Contextregulatory_region_variant
Intergenic1
Allele frequency0.56
P value3E-19
Pvalue mlog18.5228787452803
P value text
Or beta3.8
%95 Ci[2.70-4.80] % increase
PlatformAffymetrix, Illumina, Perlegen [~ 2600000] (imputed)
CNVN
Mapped traitserum gamma-glutamyl transferase measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004532
Study accessionGCST001277
PubMed ID22010049
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22010049
StudyLoci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Disease/TraitGamma gluatamyl transferase levels
Initial sample12,526 European ancestry individuals
Replication sampleNA
Region1p36.13
Chromosome idchr1
Chromosome position16178825
Reported geneintergenic
Mapped geneLOC101927479 - ARHGEF19
Upstream gene id101927479
Downstream gene id128272
SNP gene ids
Upstream gene distance10609
Downstream gene distance19031
SNP risk allelers1497406-T
SNPsrs1497406
Merged0
SNP id current1497406
Contextregulatory_region_variant
Intergenic1
Allele frequency0.41
P value0.00000004
Pvalue mlog7.39794000867203
P value text
Or beta0.078
%95 Ci[0.051-0.105] unit decrease
PlatformIllumina [2380486] (imputed)
CNVN
Mapped traitserum gamma-glutamyl transferase measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004532
Study accessionGCST001307