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SNP Detail For rs1495741
1.Mapping Information
| Human SNP ID | rs1495741 |
|---|---|
| Human chromosome | chr8 |
| Human SNP position | 18415371 |
| Pig chromosome | chr17 |
| Pig SNP position | 14143777 |
2.Annotation Information
| PubMed ID | 20686565 |
|---|---|
| Journal | Nature |
| Link | www.ncbi.nlm.nih.gov/pubmed/20686565 |
| Study | Biological, clinical and population relevance of 95 loci for blood lipids. |
| Disease/Trait | Triglycerides |
| Initial sample | 96,598 European ancestry individuals |
| Replication sample | NA |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-G |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.22 |
| P value | 0.00000000000004 |
| Pvalue mlog | 13.397940008672 |
| P value text | |
| Or beta | 2.97 |
| %95 Ci | [2.15-3.79] mg/dL increase |
| Platform | Affymetrix, Illumina, Perlegen [~ 2600000] (imputed) |
| CNV | N |
| Mapped trait | triglyceride measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004530 |
| Study accession | GCST000758 |
| PubMed ID | 20972438 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/20972438 |
| Study | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| Disease/Trait | Bladder cancer |
| Initial sample | 3,532 European ancestry cases, 5,120 European ancestry controls |
| Replication sample | 8,381 cases, 48,275 controls |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-? |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.8 |
| P value | 0.00000000004 |
| Pvalue mlog | 10.397940008672 |
| P value text | |
| Or beta | 1.15 |
| %95 Ci | [1.10-1.20] |
| Platform | Illumina [589299] |
| CNV | N |
| Mapped trait | bladder carcinoma |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000292 |
| Study accession | GCST000842 |
| PubMed ID | 20686565 |
| Journal | Nature |
| Link | www.ncbi.nlm.nih.gov/pubmed/20686565 |
| Study | Biological, clinical and population relevance of 95 loci for blood lipids. |
| Disease/Trait | Cholesterol, total |
| Initial sample | 100,184 European ancestry individuals |
| Replication sample | NA |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-G |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.32 |
| P value | 0.000000002 |
| Pvalue mlog | 8.69897000433601 |
| P value text | |
| Or beta | 1.07 |
| %95 Ci | [0.66-1.48] mg/dL increase |
| Platform | Affymetrix, Illumina, Perlegen [~ 2600000] (imputed) |
| CNV | N |
| Mapped trait | total cholesterol measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004574 |
| Study accession | GCST000760 |
| PubMed ID | 24163127 |
| Journal | Hum Mol Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/24163127 |
| Study | Genome-wide association study identifies multiple loci associated with bladder cancer risk. |
| Disease/Trait | Bladder cancer |
| Initial sample | up to 2,305 European ancestry cases, up to 3,901 European ancestry controls |
| Replication sample | up to 13,298 cases, up to 54,535 controls |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-A |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.8 |
| P value | 0.0000000002 |
| Pvalue mlog | 9.69897000433601 |
| P value text | |
| Or beta | 1.14 |
| %95 Ci | [1.09-1.18] |
| Platform | Illumina [462190] |
| CNV | N |
| Mapped trait | bladder carcinoma |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000292 |
| Study accession | GCST002240 |
| PubMed ID | 24816252 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/24816252 |
| Study | An atlas of genetic influences on human blood metabolites. |
| Disease/Trait | Blood metabolite levels |
| Initial sample | 7,824 European ancestry individuals |
| Replication sample | NA |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-A |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.78 |
| P value | 1E-27 |
| Pvalue mlog | 27 |
| P value text | (1-methylurate) |
| Or beta | 0.057 |
| %95 Ci | [0.047-0.067] unit increase |
| Platform | Affymetrix, Illumina [2100000] (imputed) |
| CNV | N |
| Mapped trait | blood metabolite measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005664 |
| Study accession | GCST002443 |
| PubMed ID | 24097068 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/24097068 |
| Study | Discovery and refinement of loci associated with lipid levels. |
| Disease/Trait | Cholesterol, total |
| Initial sample | 94,595 European ancestry individuals |
| Replication sample | 93,982 European ancestry individuals |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-G |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.26 |
| P value | 0.00000003 |
| Pvalue mlog | 7.52287874528033 |
| P value text | |
| Or beta | 0.032 |
| %95 Ci | [NR] unit increase |
| Platform | NR [NR] (imputed) |
| CNV | N |
| Mapped trait | total cholesterol measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004574 |
| Study accession | GCST002221 |
| PubMed ID | 24097068 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/24097068 |
| Study | Discovery and refinement of loci associated with lipid levels. |
| Disease/Trait | Triglycerides |
| Initial sample | 94,595 European ancestry individuals |
| Replication sample | 93,982 European ancestry individuals |
| Region | 8p22 |
| Chromosome id | chr8 |
| Chromosome position | 18415371 |
| Reported gene | NAT2 |
| Mapped gene | NAT2 - PSD3 |
| Upstream gene id | 10 |
| Downstream gene id | 23362 |
| SNP gene ids | |
| Upstream gene distance | 14152 |
| Downstream gene distance | 111932 |
| SNP risk allele | rs1495741-G |
| SNPs | rs1495741 |
| Merged | 0 |
| SNP id current | 1495741 |
| Context | intergenic_variant |
| Intergenic | 1 |
| Allele frequency | 0.26 |
| P value | 0.000000000003 |
| Pvalue mlog | 11.5228787452803 |
| P value text | |
| Or beta | 0.04 |
| %95 Ci | [NR] mg/dL increase |
| Platform | NR [NR] (imputed) |
| CNV | N |
| Mapped trait | triglyceride measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004530 |
| Study accession | GCST002216 |
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and Xi'an University of Technology ©2014-2017 All Rights Reserved.
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