Human SNP ID | rs1458038 |
---|---|
Human chromosome | chr4 |
Human SNP position | 80243569 |
Pig chromosome | chr8 |
Pig SNP position | 146723605 |
PubMed ID | 21909110 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21909110 |
Study | Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. |
Disease/Trait | Blood pressure |
Initial sample | 74,064 European ancestry individuals |
Replication sample | 48,607 European ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.3 |
P value | 0.00000000000003 |
Pvalue mlog | 13.5228787452803 |
P value text | (Mean Arterial Pressure) |
Or beta | 0.403 |
%95 Ci | [0.30-0.51] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [NR] (imputed) |
CNV | N |
Mapped trait | mean arterial pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006340 |
Study accession | GCST001236 |
PubMed ID | 21909115 |
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/21909115 |
Study | Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. |
Disease/Trait | Diastolic blood pressure |
Initial sample | 69,395 European ancestry individuals |
Replication sample | Up to 133,361 European ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.29 |
P value | 9E-25 |
Pvalue mlog | 24.0457574905606 |
P value text | |
Or beta | 0.457 |
%95 Ci | [NR] mmHg increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | diastolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006336 |
Study accession | GCST001228 |
PubMed ID | 21909115 |
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/21909115 |
Study | Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. |
Disease/Trait | Systolic blood pressure |
Initial sample | 69,395 European ancestry individuals |
Replication sample | Up to 133,361 European ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.29 |
P value | 2E-23 |
Pvalue mlog | 22.698970004336 |
P value text | |
Or beta | 0.706 |
%95 Ci | [NR] mmHg increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | systolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006335 |
Study accession | GCST001227 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Systolic blood pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.2828 |
P value | 0.00000005 |
Pvalue mlog | 7.30102999566398 |
P value text | (South Asians) |
Or beta | 0.9734 |
%95 Ci | [0.62-1.32] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [2127883] (imputed) |
CNV | N |
Mapped trait | systolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006335 |
Study accession | GCST003272 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Systolic blood pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.429 |
P value | 0.0000001 |
Pvalue mlog | 7 |
P value text | (East Asians) |
Or beta | 0.9738 |
%95 Ci | [0.61-1.33] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [2127883] (imputed) |
CNV | N |
Mapped trait | systolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006335 |
Study accession | GCST003272 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Diastolic blood pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals, 16,328 South Asian ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.3362 |
P value | 0.00000000000002 |
Pvalue mlog | 13.698970004336 |
P value text | |
Or beta | 0.4717 |
%95 Ci | [0.35-0.59] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [~ 2100000] (imputed) |
CNV | N |
Mapped trait | diastolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006336 |
Study accession | GCST003273 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Diastolic blood pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals, 16,328 South Asian ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.4297 |
P value | 0.00000003 |
Pvalue mlog | 7.52287874528033 |
P value text | (East Asians) |
Or beta | 0.6098 |
%95 Ci | [0.39-0.83] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [~ 2100000] (imputed) |
CNV | N |
Mapped trait | diastolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006336 |
Study accession | GCST003273 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Diastolic blood pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals, 16,328 South Asian ancestry individuals |
Region | 4q21.21 |
Chromosome id | chr4 |
Chromosome position | 80243569 |
Reported gene | FGF5 |
Mapped gene | PRDM8 - FGF5 |
Upstream gene id | 56978 |
Downstream gene id | 2250 |
SNP gene ids | |
Upstream gene distance | 39240 |
Downstream gene distance | 23019 |
SNP risk allele | rs1458038-T |
SNPs | rs1458038 |
Merged | 0 |
SNP id current | 1458038 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.2835 |
P value | 0.000000001 |
Pvalue mlog | 9 |
P value text | (South Asians) |
Or beta | 0.5935 |
%95 Ci | [0.4-0.79] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [~ 2100000] (imputed) |
CNV | N |
Mapped trait | diastolic blood pressure |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006336 |
Study accession | GCST003273 |