SNP Detail For rs1446468
1.Mapping Information
Human SNP ID rs1446468
Human chromosome chr2
Human SNP position 164106976
Pig chromosome chr15
Pig SNP position 78694720
2.Annotation Information
PubMed ID21909110
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21909110
StudyGenome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Disease/TraitBlood pressure
Initial sample74,064 European ancestry individuals
Replication sample48,607 European ancestry individuals
Region2q24.3
Chromosome idchr2
Chromosome position164106976
Reported geneFIGN
Mapped geneFIGN - GRB14
Upstream gene id55137
Downstream gene id2888
SNP gene ids
Upstream gene distance370779
Downstream gene distance385430
SNP risk allelers1446468-T
SNPsrs1446468
Merged0
SNP id current1446468
Contextintron_variant
Intergenic1
Allele frequency0.53
P value0.000000000006
Pvalue mlog11.2218487496163
P value text(Mean Arterial Pressure)
Or beta0.336
%95 Ci[0.24-0.44] mmHg decrease
PlatformAffymetrix, Illumina, Perlegen [NR] (imputed)
CNVN
Mapped traitmean arterial pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006340
Study accessionGCST001236
PubMed ID26390057
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26390057
StudyTrans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Disease/TraitMean arterial pressure
Initial sample31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals
Replication sample87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals
Region2q24.3
Chromosome idchr2
Chromosome position164106976
Reported geneFIGN
Mapped geneFIGN - GRB14
Upstream gene id55137
Downstream gene id2888
SNP gene ids
Upstream gene distance370779
Downstream gene distance385430
SNP risk allelers1446468-T
SNPsrs1446468
Merged0
SNP id current1446468
Contextintron_variant
Intergenic1
Allele frequency0.4878
P value0.000002
Pvalue mlog5.69897000433601
P value text
Or beta0.3106
%95 Ci[0.18-0.44] mmHg decrease
PlatformAffymetrix, Illumina, Perlegen [~ 2100000] (imputed)
CNVN
Mapped traitmean arterial pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006340
Study accessionGCST003275