SNP Detail For rs1406428
1.Mapping Information
Human SNP ID rs1406428
Human chromosome chr2
Human SNP position 51509856
Pig chromosome chr3
Pig SNP position 94523558
2.Annotation Information
PubMed ID22491018
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/22491018
StudyGenome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
Disease/TraitResponse to tocilizumab in rheumatoid arthritis
Initial sample1,157 European and other ancestry rheumatoid arthritis cases
Replication sample526 European and other ancestry rheumatoid arthritis cases
Region2p16.3
Chromosome idchr2
Chromosome position51509856
Reported geneintergenic
Mapped geneLOC730100
Upstream gene id
Downstream gene id
SNP gene ids730100
Upstream gene distance
Downstream gene distance
SNP risk allelers1406428-?
SNPsrs1406428
Merged0
SNP id current1406428
Contextintron_variant
Intergenic0
Allele frequency0.28
P value0.0000002
Pvalue mlog6.69897000433601
P value text(CSJC , RF+)
Or beta2.74
%95 Ci[NR] unit increase
PlatformIllumina [534053]
CNVN
Mapped traitrheumatoid arthritis, response to drug
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685, http://purl.obolibrary.org/obo/GO_0042493
Study accessionGCST001476