SNP Detail For rs140522
1.Mapping Information
Human SNP ID rs140522
Human chromosome chr22
Human SNP position 50532837
Pig chromosome chr5
Pig SNP position 110564546
2.Annotation Information
PubMed ID21833088
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/21833088
StudyGenetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Disease/TraitMultiple sclerosis
Initial sample9,772 European ancestry cases, 16,849 European ancestry controls
Replication sample4,218 European ancestry cases, 7,296 European ancestry controls
Region22q13.33
Chromosome idchr22
Chromosome position50532837
Reported geneODF3B, SCO2
Mapped geneODF3B - LOC102724608
Upstream gene id440836
Downstream gene id102724608
SNP gene ids
Upstream gene distance258
Downstream gene distance8577
SNP risk allelers140522-A
SNPsrs140522
Merged0
SNP id current140522
Contextupstream_gene_variant
Intergenic1
Allele frequencyNR
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta1.1
%95 Ci[1.09-1.12]
PlatformIllumina [465434]
CNVN
Mapped traitmultiple sclerosis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003885
Study accessionGCST001198
PubMed ID23222517
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/23222517
StudySeventy-five genetic loci influencing the human red blood cell.
Disease/TraitRed blood cell traits
Initial sample62,553 European ancestry individuals, 9,308 South Asian ancestry individuals
Replication sample63,506 European ancestry individuals
Region22q13.33
Chromosome idchr22
Chromosome position50532837
Reported geneTYMP, ODF3B, SCO2, NCAPH2
Mapped geneODF3B - LOC102724608
Upstream gene id440836
Downstream gene id102724608
SNP gene ids
Upstream gene distance258
Downstream gene distance8577
SNP risk allelers140522-C
SNPsrs140522
Merged0
SNP id current140522
Contextupstream_gene_variant
Intergenic1
Allele frequency0.67
P value5E-23
Pvalue mlog22.3010299956639
P value text(EA, MCV)
Or beta0.287
%95 Ci[0.23-0.35] unit increase
PlatformAffymetrix, Illumina, Perlegen [2711806] (imputed)
CNVN
Mapped traitmean corpuscular volume
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004526
Study accessionGCST001765