SNP Detail For rs1344653
1.Mapping Information
Human SNP ID rs1344653
Human chromosome chr2
Human SNP position 19531084
Pig chromosome chr3
Pig SNP position 126680693
2.Annotation Information
PubMed ID26390057
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26390057
StudyTrans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Disease/TraitPulse pressure
Initial sample31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals
Replication sample87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals
Region2p24.1
Chromosome idchr2
Chromosome position19531084
Reported geneOSR1
Mapped geneLOC105373460 - LOC105373459
Upstream gene id105373460
Downstream gene id105373459
SNP gene ids
Upstream gene distance11074
Downstream gene distance59180
SNP risk allelers1344653-A
SNPsrs1344653
Merged
SNP id current1344653
Contextintergenic_variant
Intergenic1
Allele frequency0.530994775663925
P value0.000000000008
Pvalue mlog11.096910013008
P value text
Or beta0.26579088
%95 Ci[0.19-0.34] mmHg decrease
PlatformAffymetrix, Illumina, Perlegen [~ 2100000] (imputed)
CNVN
Mapped traitpulse pressure measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005763
Study accessionGCST003274