SNP Detail For rs13146355
1.Mapping Information
Human SNP ID rs13146355
Human chromosome chr4
Human SNP position 76490987
Pig chromosome chr8
Pig SNP position 76348436
2.Annotation Information
PubMed ID20700443
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20700443
StudyGenome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.
Disease/TraitMagnesium levels
Initial sample15,366 European ancestry individuals
Replication sample8,463 European ancestry individuals
Region4q21.1
Chromosome idchr4
Chromosome position76490987
Reported geneSHROOM3
Mapped geneSHROOM3
Upstream gene id
Downstream gene id
SNP gene ids57619
Upstream gene distance
Downstream gene distance
SNP risk allelers13146355-G
SNPsrs13146355
Merged0
SNP id current13146355
Contextintron_variant
Intergenic0
Allele frequency0.56
P value0.0000000000006
Pvalue mlog12.2218487496163
P value text
Or beta0.01
%95 Ci[0.003-0.007] mmol/L decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitmagnesium measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004845
Study accessionGCST000756
PubMed ID22797727
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22797727
StudyMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Disease/TraitRenal function-related traits (sCR)
Initial sample42,257 East Asian, South Asian, and South East Asian ancestry individuals
Replication sample19,662 East Asian ancestry individuals
Region4q21.1
Chromosome idchr4
Chromosome position76490987
Reported geneSHROOM3
Mapped geneSHROOM3
Upstream gene id
Downstream gene id
SNP gene ids57619
Upstream gene distance
Downstream gene distance
SNP risk allelers13146355-A
SNPsrs13146355
Merged0
SNP id current13146355
Contextintron_variant
Intergenic0
Allele frequency0.21
P value0.000000000009
Pvalue mlog11.0457574905606
P value text
Or beta0.0047
%95 Ci[0.0033-0.0061] mg/dl increase
PlatformAffymetrix, Illumina [2353587] (imputed)
CNVN
Mapped traitrenal system measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004742
Study accessionGCST001606
PubMed ID22797727
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22797727
StudyMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Disease/TraitRenal function-related traits (eGRFcrea)
Initial sample42,451 East Asian, South Asian, and South East Asian ancestry individuals
Replication sample19,636 East Asian ancestry individuals
Region4q21.1
Chromosome idchr4
Chromosome position76490987
Reported geneSHROOM3
Mapped geneSHROOM3
Upstream gene id
Downstream gene id
SNP gene ids57619
Upstream gene distance
Downstream gene distance
SNP risk allelers13146355-A
SNPsrs13146355
Merged0
SNP id current13146355
Contextintron_variant
Intergenic0
Allele frequency0.21
P value0.00000000007
Pvalue mlog10.1549019599857
P value text
Or beta0.0051
%95 Ci[0.0035-0.0067] ml/min/1.73m2 decrease
PlatformAffymetrix, Illumina [2353587] (imputed)
CNVN
Mapped traitrenal system measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004742
Study accessionGCST001607