SNP Detail For rs12777823
1.Mapping Information
Human SNP ID rs12777823
Human chromosome chr10
Human SNP position 94645745
Pig chromosome chr14
Pig SNP position 145881620
2.Annotation Information
PubMed ID19706858
JournalJAMA
Linkwww.ncbi.nlm.nih.gov/pubmed/19706858
StudyAssociation of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
Disease/TraitResponse to clopidogrel therapy
Initial sample429 Amish individuals
Replication sample140 European ancestry individuals, 83 African American individuals, 4 individuals
Region10q23.33
Chromosome idchr10
Chromosome position94645745
Reported geneCYP2C18, CYP2C9, CYP2C8, CYP2C19
Mapped geneHELLS - CYP2C18
Upstream gene id3070
Downstream gene id1562
SNP gene ids
Upstream gene distance43646
Downstream gene distance37749
SNP risk allelers12777823-?
SNPsrs12777823
Merged0
SNP id current12777823
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.17
P value0.0000000000002
Pvalue mlog12.698970004336
P value text(Amish)
Or beta
%95 Ci
PlatformAffymetrix [400230]
CNVN
Mapped traitresponse to platelet aggregation inhibitor
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0061478
Study accessionGCST000467
PubMed ID23755828
JournalLancet
Linkwww.ncbi.nlm.nih.gov/pubmed/23755828
StudyGenetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Disease/TraitWarfarin maintenance dose
Initial sample533 African American individuals
Replication sample432 African American individuals
Region10q23.33
Chromosome idchr10
Chromosome position94645745
Reported geneCYP2C, CYP2C18, CYP2C9, CYP2C8, CYP2C19
Mapped geneHELLS - CYP2C18
Upstream gene id3070
Downstream gene id1562
SNP gene ids
Upstream gene distance43646
Downstream gene distance37749
SNP risk allelers12777823-?
SNPsrs12777823
Merged0
SNP id current12777823
Contextdownstream_gene_variant
Intergenic1
Allele frequencyNR
P value0.000000000005
Pvalue mlog11.3010299956639
P value text
Or beta
%95 Ci
PlatformIllumina [3044177] (imputed)
CNVN
Mapped traitresponse to anticoagulant
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0061476
Study accessionGCST002061