Human SNP ID | rs12463617 |
---|---|
Human chromosome | chr2 |
Human SNP position | 629244 |
Pig chromosome | chr3 |
Pig SNP position | 141870871 |
PubMed ID | 23563609 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23563609 |
Study | Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. |
Disease/Trait | Obesity (early onset extreme) |
Initial sample | 1,509 European ancestry cases, 5,380 European ancestry controls |
Replication sample | 971 European ancestry cases, 1,990 European ancestry controls |
Region | 2p25.3 |
Chromosome id | chr2 |
Chromosome position | 629244 |
Reported gene | TMEM18 |
Mapped gene | LOC105373352 - LOC105373353 |
Upstream gene id | 105373352 |
Downstream gene id | 105373353 |
SNP gene ids | |
Upstream gene distance | 67262 |
Downstream gene distance | 6393 |
SNP risk allele | rs12463617-C |
SNPs | rs12463617 |
Merged | 0 |
SNP id current | 12463617 |
Context | regulatory_region_variant |
Intergenic | 1 |
Allele frequency | 0.85 |
P value | 0.0000000000002 |
Pvalue mlog | 12.698970004336 |
P value text | |
Or beta | 1.42 |
%95 Ci | [1.29-1.56] |
Platform | Affymetrix [~ 2000000] (imputed) |
CNV | N |
Mapped trait | obesity |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001073 |
Study accession | GCST001957 |
PubMed ID | 23669352 |
Journal | Hum Mol Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23669352 |
Study | Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. |
Disease/Trait | Body mass index |
Initial sample | Up to 13,627 European ancestry individuals |
Replication sample | Up to 16,253 European ancestry individuals |
Region | 2p25.3 |
Chromosome id | chr2 |
Chromosome position | 629244 |
Reported gene | TMEM18 |
Mapped gene | LOC105373352 - LOC105373353 |
Upstream gene id | 105373352 |
Downstream gene id | 105373353 |
SNP gene ids | |
Upstream gene distance | 67262 |
Downstream gene distance | 6393 |
SNP risk allele | rs12463617-A |
SNPs | rs12463617 |
Merged | 0 |
SNP id current | 12463617 |
Context | regulatory_region_variant |
Intergenic | 1 |
Allele frequency | 0.15 |
P value | 0.00000000000000003 |
Pvalue mlog | 16.5228787452803 |
P value text | |
Or beta | 0.1 |
%95 Ci | [0.076-0.124] unit decrease |
Platform | Affymetrix, Illumina [557887] (imputed) |
CNV | N |
Mapped trait | body mass index |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
Study accession | GCST002021 |
PubMed ID | 24861553 |
Journal | Hum Mol Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24861553 |
Study | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. |
Disease/Trait | Body mass index |
Initial sample | 82,438 East Asian ancestry individuals, 4,301 South East Asian ancestry individuals |
Replication sample | Up to 47,352 East Asian ancestry individuals |
Region | 2p25.3 |
Chromosome id | chr2 |
Chromosome position | 629244 |
Reported gene | TMEM18 |
Mapped gene | LOC105373352 - LOC105373353 |
Upstream gene id | 105373352 |
Downstream gene id | 105373353 |
SNP gene ids | |
Upstream gene distance | 67262 |
Downstream gene distance | 6393 |
SNP risk allele | rs12463617-C |
SNPs | rs12463617 |
Merged | 0 |
SNP id current | 12463617 |
Context | regulatory_region_variant |
Intergenic | 1 |
Allele frequency | 0.91 |
P value | 0.000000000002 |
Pvalue mlog | 11.698970004336 |
P value text | |
Or beta | 0.0634 |
%95 Ci | [0.046-0.081] unit increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | body mass index |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
Study accession | GCST002461 |