SNP Detail For rs12455924
1.Mapping Information
Human SNP ID rs12455924
Human chromosome chr18
Human SNP position 11064410
Pig chromosome chr6
Pig SNP position 91335060
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region18p11.21
Chromosome idchr18
Chromosome position11064410
Reported geneFAM38B
Mapped genePIEZO2
Upstream gene id
Downstream gene id
SNP gene ids63895
Upstream gene distance
Downstream gene distance
SNP risk allelers12455924-T
SNPsrs12455924
Merged0
SNP id current12455924
Contextintron_variant
Intergenic0
Allele frequency0.36
P value0.0000003
Pvalue mlog6.52287874528033
P value text(AA-triglyceride response)
Or beta17.88
%95 Ci[11.04-24.72] mg/dL decrease
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, triglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST001859