SNP Detail For rs12440014
1.Mapping Information
Human SNP ID rs12440014
Human chromosome chr15
Human SNP position 78634384
Pig chromosome chr7
Pig SNP position 52822793
2.Annotation Information
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78634384
Reported geneCHRNB4
Mapped geneCHRNB4
Upstream gene id
Downstream gene id
SNP gene ids1143
Upstream gene distance
Downstream gene distance
SNP risk allelers12440014-C
SNPsrs12440014
Merged0
SNP id current12440014
Contextintron_variant
Intergenic0
Allele frequency0.782
P value0.0000000003
Pvalue mlog9.52287874528033
P value text
Or beta0.069
%95 CiNR unit decrease
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitforced expiratory volume, response to bronchodilator
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366
Study accessionGCST003262
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78634384
Reported geneCHRNB4
Mapped geneCHRNB4
Upstream gene id
Downstream gene id
SNP gene ids1143
Upstream gene distance
Downstream gene distance
SNP risk allelers12440014-C
SNPsrs12440014
Merged0
SNP id current12440014
Contextintron_variant
Intergenic0
Allele frequency0.782
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta0.013
%95 Ciunit decrease
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003264