SNP Detail For rs12424086
1.Mapping Information
Human SNP ID rs12424086
Human chromosome chr12
Human SNP position 65970729
Pig chromosome chr5
Pig SNP position 33527546
2.Annotation Information
PubMed ID21931568
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21931568
StudyGenome-wide association study identifies four loci associated with eruption of permanent teeth.
Disease/TraitPermanent tooth development
Initial sample5,088 European ancestry females
Replication sample2,994 European ancestry individuals, 161 individuals
Region12q14.3
Chromosome idchr12
Chromosome position65970729
Reported geneHMGA2
Mapped geneHMGA2 - MIR6074
Upstream gene id8091
Downstream gene id102464827
SNP gene ids
Upstream gene distance4438
Downstream gene distance52891
SNP risk allelers12424086-C
SNPsrs12424086
Merged0
SNP id current12424086
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.18
P value0.000000000002
Pvalue mlog11.698970004336
P value text
Or beta0.111
%95 Ci[0.08-0.14] unit decrease
PlatformIllumina [521741]
CNVN
Mapped traittooth eruption
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0044691
Study accessionGCST001221
PubMed ID20195514
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20195514
StudyGenome-wide association study reveals multiple loci associated with primary tooth development during infancy.
Disease/TraitPrimary tooth development (time to first tooth eruption)
Initial sample5,919 European ancestry related individuals
Replication sampleNA
Region12q14.3
Chromosome idchr12
Chromosome position65970729
Reported geneHMGA2
Mapped geneHMGA2 - MIR6074
Upstream gene id8091
Downstream gene id102464827
SNP gene ids
Upstream gene distance4438
Downstream gene distance52891
SNP risk allelers12424086-C
SNPsrs12424086
Merged0
SNP id current12424086
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.23
P value0.000008
Pvalue mlog5.09691001300805
P value text
Or beta0.29
%95 Ci[NR] % variance
PlatformIllumina [300766]
CNVN
Mapped traitodontogenesis
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0042476
Study accessionGCST000609
PubMed ID20195514
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20195514
StudyGenome-wide association study reveals multiple loci associated with primary tooth development during infancy.
Disease/TraitPrimary tooth development (number of teeth)
Initial sample5,752 European ancestry related individuals
Replication sampleNA
Region12q14.3
Chromosome idchr12
Chromosome position65970729
Reported geneHMGA2
Mapped geneHMGA2 - MIR6074
Upstream gene id8091
Downstream gene id102464827
SNP gene ids
Upstream gene distance4438
Downstream gene distance52891
SNP risk allelers12424086-C
SNPsrs12424086
Merged0
SNP id current12424086
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.23
P value0.000004
Pvalue mlog5.39794000867203
P value text
Or beta0.22
%95 Ci% variance
PlatformIllumina [300766]
CNVN
Mapped traitodontogenesis
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0042476
Study accessionGCST000610