SNP Detail For rs12143789
1.Mapping Information
Human SNP ID rs12143789
Human chromosome chr1
Human SNP position 118954531
Pig chromosome chr4
Pig SNP position 111871672
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region1p12
Chromosome idchr1
Chromosome position118954531
Reported geneTBX15
Mapped geneTBX15
Upstream gene id
Downstream gene id
SNP gene ids6913
Upstream gene distance
Downstream gene distance
SNP risk allelers12143789-C
SNPsrs12143789
Merged0
SNP id current12143789
Contextintron_variant
Intergenic0
Allele frequency0.209
P value0.000007
Pvalue mlog5.15490195998574
P value text(EA, men)
Or beta0.0274
%95 Ci[0.015-0.039] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region1p12
Chromosome idchr1
Chromosome position118954531
Reported geneTBX15
Mapped geneTBX15
Upstream gene id
Downstream gene id
SNP gene ids6913
Upstream gene distance
Downstream gene distance
SNP risk allelers12143789-C
SNPsrs12143789
Merged0
SNP id current12143789
Contextintron_variant
Intergenic0
Allele frequency0.2055
P value0.000000008
Pvalue mlog8.09691001300805
P value text(EA)
Or beta0.0244
%95 Ci[0.016-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region1p12
Chromosome idchr1
Chromosome position118954531
Reported geneTBX15
Mapped geneTBX15
Upstream gene id
Downstream gene id
SNP gene ids6913
Upstream gene distance
Downstream gene distance
SNP risk allelers12143789-C
SNPsrs12143789
Merged0
SNP id current12143789
Contextintron_variant
Intergenic0
Allele frequency0.2064
P value0.000007
Pvalue mlog5.15490195998574
P value text(men)
Or beta0.0273
%95 Ci[0.015-0.039] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region1p12
Chromosome idchr1
Chromosome position118954531
Reported geneTBX15
Mapped geneTBX15
Upstream gene id
Downstream gene id
SNP gene ids6913
Upstream gene distance
Downstream gene distance
SNP risk allelers12143789-C
SNPsrs12143789
Merged0
SNP id current12143789
Contextintron_variant
Intergenic0
Allele frequency0.2028
P value0.000000004
Pvalue mlog8.39794000867203
P value text
Or beta0.0246
%95 Ci[0.016-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782