SNP Detail For rs11978267
1.Mapping Information
Human SNP ID rs11978267
Human chromosome chr7
Human SNP position 50398606
Pig chromosome chr9
Pig SNP position 150040680
2.Annotation Information
PubMed ID19684603
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19684603
StudyGermline genomic variants associated with childhood acute lymphoblastic leukemia.
Disease/TraitAcute lymphoblastic leukemia (childhood)
Initial sample317 European ancestry cases, 17,958 European ancestry controls
Replication sampleNA
Region7p12.2
Chromosome idchr7
Chromosome position50398606
Reported geneDDC, IKZF1
Mapped geneIKZF1, LOC105375275
Upstream gene id
Downstream gene id
SNP gene ids10320, 105375275
Upstream gene distance
Downstream gene distance
SNP risk allelers11978267-G
SNPsrs11978267
Merged0
SNP id current11978267
Contextintron_variant
Intergenic0
Allele frequency0.27
P value0.00000000008
Pvalue mlog10.096910013008
P value text
Or beta1.69
%95 Ci[1.40-1.90]
PlatformAffymetrix [307944]
CNVN
Mapped traitacute lymphoblastic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000220
Study accessionGCST000464
PubMed ID22076464
JournalLeukemia
Linkwww.ncbi.nlm.nih.gov/pubmed/22076464
StudyIdentification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
Disease/TraitAcute lymphoblastic leukemia (childhood)
Initial sample419 European ancestry ETV6-RUNX1 positive cases, 474 European ancestry controls
Replication sample951 European ancestry ETV6-RUNX1 positive cases, 326 European ancestry ETV6-RUNX1 negative cases, 3,061 European ancestry controls
Region7p12.2
Chromosome idchr7
Chromosome position50398606
Reported geneIKZF1
Mapped geneIKZF1, LOC105375275
Upstream gene id
Downstream gene id
SNP gene ids10320, 105375275
Upstream gene distance
Downstream gene distance
SNP risk allelers11978267-G
SNPsrs11978267
Merged0
SNP id current11978267
Contextintron_variant
Intergenic0
Allele frequency0.27
P value0.00000000009
Pvalue mlog10.0457574905606
P value text(ETV6-RUNX1 positive)
Or beta1.43
%95 Ci[1.28 - 1.59]
PlatformAffymetrix [355750]
CNVN
Mapped traitacute lymphoblastic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000220
Study accessionGCST001320