Human SNP ID | rs11889341 |
---|---|
Human chromosome | chr2 |
Human SNP position | 191079016 |
Pig chromosome | JH118841-1 |
Pig SNP position | 51482 |
PubMed ID | 24390342 |
---|---|
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/24390342 |
Study | Genetics of rheumatoid arthritis contributes to biology and drug discovery. |
Disease/Trait | Rheumatoid arthritis |
Initial sample | up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls |
Replication sample | up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls |
Region | 2q32.2 |
Chromosome id | chr2 |
Chromosome position | 191079016 |
Reported gene | STAT4 |
Mapped gene | STAT4 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 6775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11889341-T |
SNPs | rs11889341 |
Merged | 0 |
SNP id current | 11889341 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.25 |
P value | 4E-19 |
Pvalue mlog | 18.397940008672 |
P value text | |
Or beta | 1.13 |
%95 Ci | [1.10-1.17] |
Platform | Affymetrix, Illumina [up to 9739303] (imputed) |
CNV | N |
Mapped trait | rheumatoid arthritis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000685 |
Study accession | GCST002318 |
PubMed ID | 24390342 |
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/24390342 |
Study | Genetics of rheumatoid arthritis contributes to biology and drug discovery. |
Disease/Trait | Rheumatoid arthritis |
Initial sample | up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls |
Replication sample | up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls |
Region | 2q32.2 |
Chromosome id | chr2 |
Chromosome position | 191079016 |
Reported gene | STAT4 |
Mapped gene | STAT4 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 6775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11889341-T |
SNPs | rs11889341 |
Merged | 0 |
SNP id current | 11889341 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.23 |
P value | 0.000000000001 |
Pvalue mlog | 12 |
P value text | (EA) |
Or beta | 1.12 |
%95 Ci | [1.09-1.16] |
Platform | Affymetrix, Illumina [up to 9739303] (imputed) |
CNV | N |
Mapped trait | rheumatoid arthritis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000685 |
Study accession | GCST002318 |
PubMed ID | 24390342 |
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/24390342 |
Study | Genetics of rheumatoid arthritis contributes to biology and drug discovery. |
Disease/Trait | Rheumatoid arthritis |
Initial sample | up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls |
Replication sample | up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls |
Region | 2q32.2 |
Chromosome id | chr2 |
Chromosome position | 191079016 |
Reported gene | STAT4 |
Mapped gene | STAT4 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 6775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11889341-T |
SNPs | rs11889341 |
Merged | 0 |
SNP id current | 11889341 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3 |
P value | 0.00000002 |
Pvalue mlog | 7.69897000433601 |
P value text | (East Asian) |
Or beta | 1.16 |
%95 Ci | [1.10-1.22] |
Platform | Affymetrix, Illumina [up to 9739303] (imputed) |
CNV | N |
Mapped trait | rheumatoid arthritis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000685 |
Study accession | GCST002318 |
PubMed ID | 26502338 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26502338 |
Study | Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. |
Disease/Trait | Systemic lupus erythematosus |
Initial sample | 5,201 European ancestry cases, 9,066 European ancestry controls |
Replication sample | 2,018 European ancestry cases, 6,925 European ancestry controls |
Region | 2q32.2 |
Chromosome id | chr2 |
Chromosome position | 191079016 |
Reported gene | STAT4 |
Mapped gene | STAT4 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 6775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11889341-T |
SNPs | rs11889341 |
Merged | 0 |
SNP id current | 11889341 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | |
P value | 6E-122 |
Pvalue mlog | 121.221848749616 |
P value text | |
Or beta | 1.73 |
%95 Ci | (1.65鈥?.81] |
Platform | Illumina [644674] |
CNV | N |
Mapped trait | systemic lupus erythematosus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0002690 |
Study accession | GCST003155 |
PubMed ID | 26502338 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26502338 |
Study | Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. |
Disease/Trait | Systemic lupus erythematosus |
Initial sample | 5,201 European ancestry cases, 9,066 European ancestry controls |
Replication sample | NA |
Region | 2q32.2 |
Chromosome id | chr2 |
Chromosome position | 191079016 |
Reported gene | STAT4 |
Mapped gene | STAT4 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 6775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11889341-T |
SNPs | rs11889341 |
Merged | 0 |
SNP id current | 11889341 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | |
P value | 2E-76 |
Pvalue mlog | 75.698970004336 |
P value text | |
Or beta | 1.68 |
%95 Ci | [NR] |
Platform | Illumina [> 644674] (imputed) |
CNV | N |
Mapped trait | systemic lupus erythematosus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0002690 |
Study accession | GCST003156 |
PubMed ID | 26606652 |
Journal | Arthritis Rheumatol |
Link | www.ncbi.nlm.nih.gov/pubmed/26606652 |
Study | GWAS in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture. |
Disease/Trait | Systemic lupus erythematosus |
Initial sample | 862 Native American ancestry-enriched North American cases, 531 Native American ancestry-enriched South American cases, 1,973 Native American ancestry-enriched North American controls, 344 Native American ancestry-enriched South American controls |
Replication sample | NA |
Region | 2q32.2 |
Chromosome id | chr2 |
Chromosome position | 191079016 |
Reported gene | STAT4 |
Mapped gene | STAT4 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 6775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11889341-T |
SNPs | rs11889341 |
Merged | 0 |
SNP id current | 11889341 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.407 |
P value | 0.0000000000007 |
Pvalue mlog | 12.1549019599857 |
P value text | |
Or beta | 1.5 |
%95 Ci | [1.36-1.66] |
Platform | Illumina [580483] (imputed) |
CNV | N |
Mapped trait | systemic lupus erythematosus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0002690 |
Study accession | GCST003252 |