SNP Detail For rs11676272
1.Mapping Information
Human SNP ID rs11676272
Human chromosome chr2
Human SNP position 24918669
Pig chromosome chr3
Pig SNP position 121107462
2.Annotation Information
PubMed ID25044758
JournalObesity (Silver Spring)
Linkwww.ncbi.nlm.nih.gov/pubmed/25044758
StudyGenome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.
Disease/TraitHeight adjusted BMI
Initial sample5,809 children
Replication sample2,089 European ancestry children
Region2p23.3
Chromosome idchr2
Chromosome position24918669
Reported geneADCY3
Mapped geneADCY3
Upstream gene id
Downstream gene id
SNP gene ids109
Upstream gene distance
Downstream gene distance
SNP risk allelers11676272-G
SNPsrs11676272
Merged0
SNP id current11676272
Contextmissense_variant
Intergenic0
Allele frequency0.48
P value0.000000004
Pvalue mlog8.39794000867203
P value text
Or beta0.2
%95 Ci[0.13-0.27] unit increase
PlatformIllumina [2608006] (imputed)
CNVN
Mapped traitheight-adjusted body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005851
Study accessionGCST002538
PubMed ID25953783
JournalInt J Epidemiol
Linkwww.ncbi.nlm.nih.gov/pubmed/25953783
StudyA genome-wide association study of body mass index across early life and childhood.
Disease/TraitBody mass index
Initial sample9,377 children and adolescents
Replication sample3,918 European ancestry children and adolescents
Region2p23.3
Chromosome idchr2
Chromosome position24918669
Reported geneADCY3
Mapped geneADCY3
Upstream gene id
Downstream gene id
SNP gene ids109
Upstream gene distance
Downstream gene distance
SNP risk allelers11676272-A
SNPsrs11676272
Merged0
SNP id current11676272
Contextmissense_variant
Intergenic0
Allele frequency0.514
P value0.00000000001
Pvalue mlog11
P value text(age 8)
Or beta0.011
%95 Ci[0.0071-0.0149] unit decrease
PlatformIllumina [~ 2200000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002894
PubMed ID25953783
JournalInt J Epidemiol
Linkwww.ncbi.nlm.nih.gov/pubmed/25953783
StudyA genome-wide association study of body mass index across early life and childhood.
Disease/TraitBody mass index
Initial sample9,377 children and adolescents
Replication sample3,918 European ancestry children and adolescents
Region2p23.3
Chromosome idchr2
Chromosome position24918669
Reported geneADCY3
Mapped geneADCY3
Upstream gene id
Downstream gene id
SNP gene ids109
Upstream gene distance
Downstream gene distance
SNP risk allelers11676272-A
SNPsrs11676272
Merged0
SNP id current11676272
Contextmissense_variant
Intergenic0
Allele frequency0.514
P value0.0000000001
Pvalue mlog10
P value text(age 1-17)
Or beta
%95 Ci
PlatformIllumina [~ 2200000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002894
PubMed ID26604143
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26604143
StudyGenome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Disease/TraitChildhood body mass index
Initial sample34,744 European ancestry children
Replication sample11,313 European ancestry children
Region2p23.3
Chromosome idchr2
Chromosome position24918669
Reported geneADCY3
Mapped geneADCY3
Upstream gene id
Downstream gene id
SNP gene ids109
Upstream gene distance
Downstream gene distance
SNP risk allelers11676272-G
SNPsrs11676272
Merged0
SNP id current11676272
Contextmissense_variant
Intergenic0
Allele frequency0.46
P value7E-23
Pvalue mlog22.1549019599857
P value text
Or beta0.068
%95 Ci[0.054-0.082] unit increase
PlatformAffymetrix, Illumina [2499691] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST003177