Human SNP ID | rs1154155 |
---|---|
Human chromosome | chr14 |
Human SNP position | 22533736 |
Pig chromosome | chr7 |
Pig SNP position | 81720575 |
PubMed ID | 19412176 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19412176 |
Study | Narcolepsy is strongly associated with the T-cell receptor alpha locus. |
Disease/Trait | Narcolepsy |
Initial sample | 807 European ancestry cases, 1,074 European ancestry controls |
Replication sample | 363 European ancestry cases, 355 European ancestry controls, 133 African American cases, 144 African American controls, 561 Asian ancestry cases, 605 Asian ancestry controls |
Region | 14q11.2 |
Chromosome id | chr14 |
Chromosome position | 22533736 |
Reported gene | TRA-alpha, TRAJ10 |
Mapped gene | TRAJ10 - TRAJ9 |
Upstream gene id | 28745 |
Downstream gene id | 28746 |
SNP gene ids | |
Upstream gene distance | 176 |
Downstream gene distance | 1818 |
SNP risk allele | rs1154155-C |
SNPs | rs1154155 |
Merged | 0 |
SNP id current | 1154155 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | 0.14 |
P value | 3E-22 |
Pvalue mlog | 21.5228787452803 |
P value text | |
Or beta | 1.69 |
%95 Ci | [1.52-1.88] |
Platform | Affymetrix [549596] |
CNV | N |
Mapped trait | narcolepsy with cataplexy |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000614 |
Study accession | GCST000385 |
PubMed ID | 20711174 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20711174 |
Study | Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. |
Disease/Trait | Narcolepsy |
Initial sample | 562 European ancestry cases, 702 European ancestry controls |
Replication sample | 370 cases, 495 controls |
Region | 14q11.2 |
Chromosome id | chr14 |
Chromosome position | 22533736 |
Reported gene | TRA@ |
Mapped gene | TRAJ10 - TRAJ9 |
Upstream gene id | 28745 |
Downstream gene id | 28746 |
SNP gene ids | |
Upstream gene distance | 176 |
Downstream gene distance | 1818 |
SNP risk allele | rs1154155-G |
SNPs | rs1154155 |
Merged | 0 |
SNP id current | 1154155 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | 0.15 |
P value | 0.0000005 |
Pvalue mlog | 6.30102999566398 |
P value text | |
Or beta | 1.54 |
%95 Ci | [1.30-1.95] |
Platform | Affymetrix [392949] |
CNV | N |
Mapped trait | narcolepsy with cataplexy |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000614 |
Study accession | GCST000771 |
PubMed ID | 24204295 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24204295 |
Study | Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. |
Disease/Trait | Narcolepsy |
Initial sample | 1,189 Chinese ancestry cases, 1,997 Chinese ancestry controls |
Replication sample | 2,693 European ancestry cases, 11,495 European ancestry controls |
Region | 14q11.2 |
Chromosome id | chr14 |
Chromosome position | 22533736 |
Reported gene | TRA |
Mapped gene | TRAJ10 - TRAJ9 |
Upstream gene id | 28745 |
Downstream gene id | 28746 |
SNP gene ids | |
Upstream gene distance | 176 |
Downstream gene distance | 1818 |
SNP risk allele | rs1154155-G |
SNPs | rs1154155 |
Merged | 0 |
SNP id current | 1154155 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | 0.148 |
P value | 5E-49 |
Pvalue mlog | 48.3010299956639 |
P value text | |
Or beta | 1.64 |
%95 Ci | [1.53-1.75] |
Platform | Affymetrix [603382] |
CNV | N |
Mapped trait | narcolepsy with cataplexy |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000614 |
Study accession | GCST002260 |
PubMed ID | 25986216 |
Journal | Brain Behav Immun |
Link | www.ncbi.nlm.nih.gov/pubmed/25986216 |
Study | A polymorphism in CCR1/CCR3 is associated with narcolepsy. |
Disease/Trait | Narcolepsy with cataplexy |
Initial sample | 409 Japanese ancestry cases, 1,562 Japanese ancestry controls |
Replication sample | 240 Japanese ancestry cases, 869 Japanese ancestry controls |
Region | 14q11.2 |
Chromosome id | chr14 |
Chromosome position | 22533736 |
Reported gene | TCRA |
Mapped gene | TRAJ10 - TRAJ9 |
Upstream gene id | 28745 |
Downstream gene id | 28746 |
SNP gene ids | |
Upstream gene distance | 176 |
Downstream gene distance | 1818 |
SNP risk allele | rs1154155-C |
SNPs | rs1154155 |
Merged | 0 |
SNP id current | 1154155 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | 0.431 |
P value | 0.00000000001 |
Pvalue mlog | 11 |
P value text | |
Or beta | 1.71 |
%95 Ci | [NR] |
Platform | Affymetrix [525196] |
CNV | N |
Mapped trait | narcolepsy with cataplexy |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000614 |
Study accession | GCST002912 |