SNP Detail For rs1154155
1.Mapping Information
Human SNP ID rs1154155
Human chromosome chr14
Human SNP position 22533736
Pig chromosome chr7
Pig SNP position 81720575
2.Annotation Information
PubMed ID19412176
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19412176
StudyNarcolepsy is strongly associated with the T-cell receptor alpha locus.
Disease/TraitNarcolepsy
Initial sample807 European ancestry cases, 1,074 European ancestry controls
Replication sample363 European ancestry cases, 355 European ancestry controls, 133 African American cases, 144 African American controls, 561 Asian ancestry cases, 605 Asian ancestry controls
Region14q11.2
Chromosome idchr14
Chromosome position22533736
Reported geneTRA-alpha, TRAJ10
Mapped geneTRAJ10 - TRAJ9
Upstream gene id28745
Downstream gene id28746
SNP gene ids
Upstream gene distance176
Downstream gene distance1818
SNP risk allelers1154155-C
SNPsrs1154155
Merged0
SNP id current1154155
Contextintron_variant
Intergenic1
Allele frequency0.14
P value3E-22
Pvalue mlog21.5228787452803
P value text
Or beta1.69
%95 Ci[1.52-1.88]
PlatformAffymetrix [549596]
CNVN
Mapped traitnarcolepsy with cataplexy
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000614
Study accessionGCST000385
PubMed ID20711174
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20711174
StudyGenome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
Disease/TraitNarcolepsy
Initial sample562 European ancestry cases, 702 European ancestry controls
Replication sample370 cases, 495 controls
Region14q11.2
Chromosome idchr14
Chromosome position22533736
Reported geneTRA@
Mapped geneTRAJ10 - TRAJ9
Upstream gene id28745
Downstream gene id28746
SNP gene ids
Upstream gene distance176
Downstream gene distance1818
SNP risk allelers1154155-G
SNPsrs1154155
Merged0
SNP id current1154155
Contextintron_variant
Intergenic1
Allele frequency0.15
P value0.0000005
Pvalue mlog6.30102999566398
P value text
Or beta1.54
%95 Ci[1.30-1.95]
PlatformAffymetrix [392949]
CNVN
Mapped traitnarcolepsy with cataplexy
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000614
Study accessionGCST000771
PubMed ID24204295
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24204295
StudyGenome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
Disease/TraitNarcolepsy
Initial sample1,189 Chinese ancestry cases, 1,997 Chinese ancestry controls
Replication sample2,693 European ancestry cases, 11,495 European ancestry controls
Region14q11.2
Chromosome idchr14
Chromosome position22533736
Reported geneTRA
Mapped geneTRAJ10 - TRAJ9
Upstream gene id28745
Downstream gene id28746
SNP gene ids
Upstream gene distance176
Downstream gene distance1818
SNP risk allelers1154155-G
SNPsrs1154155
Merged0
SNP id current1154155
Contextintron_variant
Intergenic1
Allele frequency0.148
P value5E-49
Pvalue mlog48.3010299956639
P value text
Or beta1.64
%95 Ci[1.53-1.75]
PlatformAffymetrix [603382]
CNVN
Mapped traitnarcolepsy with cataplexy
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000614
Study accessionGCST002260
PubMed ID25986216
JournalBrain Behav Immun
Linkwww.ncbi.nlm.nih.gov/pubmed/25986216
StudyA polymorphism in CCR1/CCR3 is associated with narcolepsy.
Disease/TraitNarcolepsy with cataplexy
Initial sample409 Japanese ancestry cases, 1,562 Japanese ancestry controls
Replication sample240 Japanese ancestry cases, 869 Japanese ancestry controls
Region14q11.2
Chromosome idchr14
Chromosome position22533736
Reported geneTCRA
Mapped geneTRAJ10 - TRAJ9
Upstream gene id28745
Downstream gene id28746
SNP gene ids
Upstream gene distance176
Downstream gene distance1818
SNP risk allelers1154155-C
SNPsrs1154155
Merged0
SNP id current1154155
Contextintron_variant
Intergenic1
Allele frequency0.431
P value0.00000000001
Pvalue mlog11
P value text
Or beta1.71
%95 Ci[NR]
PlatformAffymetrix [525196]
CNVN
Mapped traitnarcolepsy with cataplexy
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000614
Study accessionGCST002912