SNP Detail For rs11257655
1.Mapping Information
Human SNP ID rs11257655
Human chromosome chr10
Human SNP position 12265895
Pig chromosome chr10
Pig SNP position 65480897
2.Annotation Information
PubMed ID22961080
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/22961080
StudyA genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Disease/TraitType 2 diabetes
Initial sample1,839 Han Chinese ancestry cases, 1,873 Han Chinese ancestry controls
Replication sample15,979 East Asian ancestry cases, 19,360 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls
Region10p13
Chromosome idchr10
Chromosome position12265895
Reported geneCDC123
Mapped geneCDC123 - CAMK1D
Upstream gene id8872
Downstream gene id57118
SNP gene ids
Upstream gene distance15305
Downstream gene distance83622
SNP risk allelers11257655-T
SNPsrs11257655
Merged0
SNP id current11257655
Contextregulatory_region_variant
Intergenic1
Allele frequency0.564
P value0.000000007
Pvalue mlog8.15490195998574
P value text
Or beta1.15
%95 Ci[1.10-1.20]
PlatformIllumina [2234194] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST001666
PubMed ID24509480
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24509480
StudyGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Disease/TraitType 2 diabetes
Initial sample12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance
Replication sample21,491 European ancestry cases, 55,647 European ancestry controls
Region10p13
Chromosome idchr10
Chromosome position12265895
Reported geneCDC123
Mapped geneCDC123 - CAMK1D
Upstream gene id8872
Downstream gene id57118
SNP gene ids
Upstream gene distance15305
Downstream gene distance83622
SNP risk allelers11257655-T
SNPsrs11257655
Merged0
SNP id current11257655
Contextregulatory_region_variant
Intergenic1
Allele frequency0.23
P value0.000000003
Pvalue mlog8.52287874528033
P value text
Or beta1.06
%95 Ci[1.01-1.11]
PlatformAffymetrix, Illumina [2500000] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002352