SNP Detail For rs11222084
1.Mapping Information
Human SNP ID rs11222084
Human chromosome chr11
Human SNP position 130403335
Pig chromosome chr9
Pig SNP position 63359046
2.Annotation Information
PubMed ID21909110
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21909110
StudyGenome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Disease/TraitBlood pressure
Initial sample74,064 European ancestry individuals
Replication sample48,607 European ancestry individuals
Region11q24.3
Chromosome idchr11
Chromosome position130403335
Reported geneADAMTS-8
Mapped geneLOC646383
Upstream gene id
Downstream gene id
SNP gene ids646383
Upstream gene distance
Downstream gene distance
SNP risk allelers11222084-T
SNPsrs11222084
Merged0
SNP id current11222084
Contextnon_coding_transcript_exon_variant
Intergenic0
Allele frequency0.38
P value0.00000000002
Pvalue mlog10.698970004336
P value text(Pulse Pressure)
Or beta0.337
%95 Ci[0.24-0.44] mmHg increase
PlatformAffymetrix, Illumina, Perlegen [NR] (imputed)
CNVN
Mapped traitpulse pressure measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005763
Study accessionGCST001235
PubMed ID26390057
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26390057
StudyTrans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Disease/TraitPulse pressure
Initial sample31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals
Replication sample87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals
Region11q24.3
Chromosome idchr11
Chromosome position130403335
Reported geneADAMTS8
Mapped geneLOC646383
Upstream gene id
Downstream gene id
SNP gene ids646383
Upstream gene distance
Downstream gene distance
SNP risk allelers11222084-A
SNPsrs11222084
Merged0
SNP id current11222084
Contextnon_coding_transcript_exon_variant
Intergenic0
Allele frequency0.613
P value0.000004
Pvalue mlog5.39794000867203
P value text(EA)
Or beta0.4993
%95 Ci[0.29-0.71] mmHg decrease
PlatformAffymetrix, Illumina, Perlegen [~ 2100000] (imputed)
CNVN
Mapped traitpulse pressure measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005763
Study accessionGCST003274