Human SNP ID | rs11222084 |
---|---|
Human chromosome | chr11 |
Human SNP position | 130403335 |
Pig chromosome | chr9 |
Pig SNP position | 63359046 |
PubMed ID | 21909110 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21909110 |
Study | Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. |
Disease/Trait | Blood pressure |
Initial sample | 74,064 European ancestry individuals |
Replication sample | 48,607 European ancestry individuals |
Region | 11q24.3 |
Chromosome id | chr11 |
Chromosome position | 130403335 |
Reported gene | ADAMTS-8 |
Mapped gene | LOC646383 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 646383 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11222084-T |
SNPs | rs11222084 |
Merged | 0 |
SNP id current | 11222084 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | 0.38 |
P value | 0.00000000002 |
Pvalue mlog | 10.698970004336 |
P value text | (Pulse Pressure) |
Or beta | 0.337 |
%95 Ci | [0.24-0.44] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [NR] (imputed) |
CNV | N |
Mapped trait | pulse pressure measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005763 |
Study accession | GCST001235 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Pulse pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals |
Region | 11q24.3 |
Chromosome id | chr11 |
Chromosome position | 130403335 |
Reported gene | ADAMTS8 |
Mapped gene | LOC646383 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 646383 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11222084-A |
SNPs | rs11222084 |
Merged | 0 |
SNP id current | 11222084 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | 0.613 |
P value | 0.000004 |
Pvalue mlog | 5.39794000867203 |
P value text | (EA) |
Or beta | 0.4993 |
%95 Ci | [0.29-0.71] mmHg decrease |
Platform | Affymetrix, Illumina, Perlegen [~ 2100000] (imputed) |
CNV | N |
Mapped trait | pulse pressure measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005763 |
Study accession | GCST003274 |