SNP Detail For rs11220462
1.Mapping Information
Human SNP ID rs11220462
Human chromosome chr11
Human SNP position 126374057
Pig chromosome chr9
Pig SNP position 59307547
2.Annotation Information
PubMed ID20686565
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/20686565
StudyBiological, clinical and population relevance of 95 loci for blood lipids.
Disease/TraitLDL cholesterol
Initial sample95,454 European ancestry individuals
Replication sampleNA
Region11q24.2
Chromosome idchr11
Chromosome position126374057
Reported geneST3GAL4
Mapped geneST3GAL4
Upstream gene id
Downstream gene id
SNP gene ids6484
Upstream gene distance
Downstream gene distance
SNP risk allelers11220462-A
SNPsrs11220462
Merged0
SNP id current11220462
Contextintron_variant
Intergenic0
Allele frequency0.14
P value0.000000000000001
Pvalue mlog15
P value text
Or beta1.95
%95 Ci[1.44-2.46] mg/dL increase
PlatformAffymetrix, Illumina, Perlegen [~ 2600000] (imputed)
CNVN
Mapped traitlow density lipoprotein cholesterol measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004611
Study accessionGCST000759
PubMed ID20686565
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/20686565
StudyBiological, clinical and population relevance of 95 loci for blood lipids.
Disease/TraitCholesterol, total
Initial sample100,184 European ancestry individuals
Replication sampleNA
Region11q24.2
Chromosome idchr11
Chromosome position126374057
Reported geneST3GAL4
Mapped geneST3GAL4
Upstream gene id
Downstream gene id
SNP gene ids6484
Upstream gene distance
Downstream gene distance
SNP risk allelers11220462-T
SNPsrs11220462
Merged0
SNP id current11220462
Contextintron_variant
Intergenic0
Allele frequency0.11
P value0.00000000002
Pvalue mlog10.698970004336
P value text
Or beta2.01
%95 Ci[1.36-2.66] mg/dL increase
PlatformAffymetrix, Illumina, Perlegen [~ 2600000] (imputed)
CNVN
Mapped traittotal cholesterol measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004574
Study accessionGCST000760
PubMed ID24097068
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24097068
StudyDiscovery and refinement of loci associated with lipid levels.
Disease/TraitLDL cholesterol
Initial sample94,595 European ancestry individuals
Replication sample93,982 European ancestry individuals
Region11q24.2
Chromosome idchr11
Chromosome position126374057
Reported geneST3GAL4
Mapped geneST3GAL4
Upstream gene id
Downstream gene id
SNP gene ids6484
Upstream gene distance
Downstream gene distance
SNP risk allelers11220462-A
SNPsrs11220462
Merged0
SNP id current11220462
Contextintron_variant
Intergenic0
Allele frequency0.14
P value7E-21
Pvalue mlog20.1549019599857
P value text
Or beta0.059
%95 Ci[NR] unit increase
PlatformNR [NR] (imputed)
CNVN
Mapped traitlow density lipoprotein cholesterol measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004611
Study accessionGCST002222
PubMed ID24097068
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24097068
StudyDiscovery and refinement of loci associated with lipid levels.
Disease/TraitCholesterol, total
Initial sample94,595 European ancestry individuals
Replication sample93,982 European ancestry individuals
Region11q24.2
Chromosome idchr11
Chromosome position126374057
Reported geneST3GAL4
Mapped geneST3GAL4
Upstream gene id
Downstream gene id
SNP gene ids6484
Upstream gene distance
Downstream gene distance
SNP risk allelers11220462-A
SNPsrs11220462
Merged0
SNP id current11220462
Contextintron_variant
Intergenic0
Allele frequency0.14
P value0.000000000000006
Pvalue mlog14.2218487496163
P value text
Or beta0.047
%95 Ci[NR] unit increase
PlatformNR [NR] (imputed)
CNVN
Mapped traittotal cholesterol measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004574
Study accessionGCST002221