SNP Detail For rs11216831
1.Mapping Information
Human SNP ID rs11216831
Human chromosome chr11
Human SNP position 118246303
Pig chromosome chr9
Pig SNP position 50600346
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region11q23.3
Chromosome idchr11
Chromosome position118246303
Reported genePHLDB1
Mapped geneMPZL3
Upstream gene id
Downstream gene id
SNP gene ids196264
Upstream gene distance
Downstream gene distance
SNP risk allelers11216831-A
SNPsrs11216831
Merged0
SNP id current11216831
Contextintron_variant
Intergenic0
Allele frequency0.07
P value0.000004
Pvalue mlog5.39794000867203
P value text(EA-triglyceride response)
Or beta42.47
%95 Ci[24.4-60.54] mg/dL increase
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, triglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST001859