Human SNP ID | rs11216831 |
---|---|
Human chromosome | chr11 |
Human SNP position | 118246303 |
Pig chromosome | chr9 |
Pig SNP position | 50600346 |
PubMed ID | 23400010 |
---|---|
Journal | Pharmacogenomics J |
Link | www.ncbi.nlm.nih.gov/pubmed/23400010 |
Study | Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. |
Disease/Trait | Thiazide-induced adverse metabolic effects in hypertensive patients |
Initial sample | 425 European ancestry cases, 342 African American cases |
Replication sample | NA |
Region | 11q23.3 |
Chromosome id | chr11 |
Chromosome position | 118246303 |
Reported gene | PHLDB1 |
Mapped gene | MPZL3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 196264 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs11216831-A |
SNPs | rs11216831 |
Merged | 0 |
SNP id current | 11216831 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.07 |
P value | 0.000004 |
Pvalue mlog | 5.39794000867203 |
P value text | (EA-triglyceride response) |
Or beta | 42.47 |
%95 Ci | [24.4-60.54] mg/dL increase |
Platform | Affymetrix, Illumina [> 2000000] (imputed) |
CNV | N |
Mapped trait | response to hydrochlorothiazide, triglyceride measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530 |
Study accession | GCST001859 |