SNP Detail For rs1111875
1.Mapping Information
Human SNP ID rs1111875
Human chromosome chr10
Human SNP position 92703125
Pig chromosome chr14
Pig SNP position 113806996
2.Annotation Information
PubMed ID17293876
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/17293876
StudyA genome-wide association study identifies novel risk loci for type 2 diabetes.
Disease/TraitType 2 diabetes
Initial sample661 European ancestry cases, 614 European ancestry controls
Replication sample2,617 European ancestry cases, 2,894 European ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position92703125
Reported geneHHEX
Mapped geneHHEX - EXOC6
Upstream gene id3087
Downstream gene id54536
SNP gene ids
Upstream gene distance7474
Downstream gene distance131588
SNP risk allelers1111875-G
SNPsrs1111875
Merged0
SNP id current1111875
Contextintergenic_variant
Intergenic1
Allele frequency0.6
P value0.000003
Pvalue mlog5.52287874528033
P value text
Or beta1.19
%95 Ci[0.82-1.56]
PlatformIllumina [392935]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000012
PubMed ID17463246
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463246
StudyGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Disease/TraitType 2 diabetes
Initial sample1,464 European ancestry cases, 1,467 European ancestry controls
Replication sample5,065 European ancestry cases, 5,785 European ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position92703125
Reported geneHHEX
Mapped geneHHEX - EXOC6
Upstream gene id3087
Downstream gene id54536
SNP gene ids
Upstream gene distance7474
Downstream gene distance131588
SNP risk allelers1111875-C
SNPsrs1111875
Merged0
SNP id current1111875
Contextintergenic_variant
Intergenic1
Allele frequency0.53
P value0.0000000006
Pvalue mlog9.22184874961635
P value text(DGI+FUSION+WTCCC)
Or beta1.13
%95 Ci[1.08-1.17]
PlatformAffymetrix [386731]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000028
PubMed ID19401414
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/19401414
StudyConfirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
Disease/TraitType 2 diabetes
Initial sample519 Japanese ancestry cases, 503 Japanese ancestry controls
Replication sample5,110 Japanese ancestry cases, 6,867 Japanese ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position92703125
Reported geneHHEX
Mapped geneHHEX - EXOC6
Upstream gene id3087
Downstream gene id54536
SNP gene ids
Upstream gene distance7474
Downstream gene distance131588
SNP risk allelers1111875-C
SNPsrs1111875
Merged0
SNP id current1111875
Contextintergenic_variant
Intergenic1
Allele frequency0.28
P value0.000000000007
Pvalue mlog11.1549019599857
P value text
Or beta1.21
%95 Ci[1.15-1.28]
PlatformIllumina [482625]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000383
PubMed ID17463248
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463248
StudyA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Disease/TraitType 2 diabetes
Initial sample1,161 European ancestry cases, 1,174 European ancestry controls
Replication sample1,215 European ancestry cases, 1,258 European ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position92703125
Reported geneHHEX
Mapped geneHHEX - EXOC6
Upstream gene id3087
Downstream gene id54536
SNP gene ids
Upstream gene distance7474
Downstream gene distance131588
SNP risk allelers1111875-C
SNPsrs1111875
Merged0
SNP id current1111875
Contextintergenic_variant
Intergenic1
Allele frequency0.52
P value0.0000000006
Pvalue mlog9.22184874961635
P value text(DGI+FUSION+WTCCC)
Or beta1.13
%95 Ci[1.09-1.17]
PlatformIllumina [315635]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000024
PubMed ID23945395
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23945395
StudyGenome-wide association study identifies three novel loci for type 2 diabetes.
Disease/TraitType 2 diabetes
Initial sample5,976 Japanese ancestry cases, 20,829 Japanese ancestry controls
Replication sample24,416 East Asian ancestry cases, 13,985 East Asian ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position92703125
Reported geneHHEX
Mapped geneHHEX - EXOC6
Upstream gene id3087
Downstream gene id54536
SNP gene ids
Upstream gene distance7474
Downstream gene distance131588
SNP risk allelers1111875-C
SNPsrs1111875
Merged0
SNP id current1111875
Contextintergenic_variant
Intergenic1
Allele frequency0.29
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta1.14
%95 Ci[1.09-1.20]
PlatformIllumina [6209637] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002128
PubMed ID24509480
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24509480
StudyGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Disease/TraitType 2 diabetes
Initial sample12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance
Replication sample21,491 European ancestry cases, 55,647 European ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position92703125
Reported geneHHEX, IDE
Mapped geneHHEX - EXOC6
Upstream gene id3087
Downstream gene id54536
SNP gene ids
Upstream gene distance7474
Downstream gene distance131588
SNP risk allelers1111875-C
SNPsrs1111875
Merged0
SNP id current1111875
Contextintergenic_variant
Intergenic1
Allele frequency0.58
P value3E-19
Pvalue mlog18.5228787452803
P value text
Or beta1.15
%95 Ci[1.11-1.19]
PlatformAffymetrix, Illumina [2500000] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002352