SNP Detail For rs10991437
1.Mapping Information
Human SNP ID rs10991437
Human chromosome chr9
Human SNP position 104973639
Pig chromosome chr1
Pig SNP position 275917294
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region9q31.1
Chromosome idchr9
Chromosome position104973639
Reported geneABCA1
Mapped geneLOC105376196 - LOC105376197
Upstream gene id105376196
Downstream gene id105376197
SNP gene ids
Upstream gene distance34589
Downstream gene distance117876
SNP risk allelers10991437-A
SNPsrs10991437
Merged0
SNP id current10991437
Contextintergenic_variant
Intergenic1
Allele frequency0.1142
P value0.00000003
Pvalue mlog7.52287874528033
P value text(EA, women)
Or beta0.0399
%95 Ci[0.026-0.054] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region9q31.1
Chromosome idchr9
Chromosome position104973639
Reported geneABCA1
Mapped geneLOC105376196 - LOC105376197
Upstream gene id105376196
Downstream gene id105376197
SNP gene ids
Upstream gene distance34589
Downstream gene distance117876
SNP risk allelers10991437-A
SNPsrs10991437
Merged0
SNP id current10991437
Contextintergenic_variant
Intergenic1
Allele frequency0.1135
P value0.00000001
Pvalue mlog8
P value text(EA)
Or beta0.0311
%95 Ci[0.021-0.042] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region9q31.1
Chromosome idchr9
Chromosome position104973639
Reported geneABCA1
Mapped geneLOC105376196 - LOC105376197
Upstream gene id105376196
Downstream gene id105376197
SNP gene ids
Upstream gene distance34589
Downstream gene distance117876
SNP risk allelers10991437-A
SNPsrs10991437
Merged0
SNP id current10991437
Contextintergenic_variant
Intergenic1
Allele frequency0.1149
P value0.00000001
Pvalue mlog8
P value text(women)
Or beta0.0402
%95 Ci[0.026-0.054] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region9q31.1
Chromosome idchr9
Chromosome position104973639
Reported geneABCA1
Mapped geneLOC105376196 - LOC105376197
Upstream gene id105376196
Downstream gene id105376197
SNP gene ids
Upstream gene distance34589
Downstream gene distance117876
SNP risk allelers10991437-A
SNPsrs10991437
Merged0
SNP id current10991437
Contextintergenic_variant
Intergenic1
Allele frequency0.1147
P value0.000000009
Pvalue mlog8.04575749056067
P value text
Or beta0.0305
%95 Ci[0.02-0.041] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782