SNP Detail For rs10968576
1.Mapping Information
Human SNP ID rs10968576
Human chromosome chr9
Human SNP position 28414341
Pig chromosome chr10
Pig SNP position 42575256
2.Annotation Information
PubMed ID20935630
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20935630
StudyAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Disease/TraitBody mass index
Initial sampleUp to 123,865 European ancestry individuals
Replication sampleUp to 125,931 European ancestry individuals
Region9p21.1
Chromosome idchr9
Chromosome position28414341
Reported geneLRRN6C
Mapped geneLINGO2
Upstream gene id
Downstream gene id
SNP gene ids158038
Upstream gene distance
Downstream gene distance
SNP risk allelers10968576-G
SNPsrs10968576
Merged0
SNP id current10968576
Contextintron_variant
Intergenic0
Allele frequency0.31
P value0.0000000000003
Pvalue mlog12.5228787452803
P value text
Or beta0.11
%95 Ci[0.07-0.15] kg/m2 increase
PlatformAffymetrix, Illumina, Perlegen [~ 2800000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST000830
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region9p21.1
Chromosome idchr9
Chromosome position28414341
Reported geneLINGO2
Mapped geneLINGO2
Upstream gene id
Downstream gene id
SNP gene ids158038
Upstream gene distance
Downstream gene distance
SNP risk allelers10968576-G
SNPsrs10968576
Merged0
SNP id current10968576
Contextintron_variant
Intergenic0
Allele frequency0.32
P value0.00000003
Pvalue mlog7.52287874528033
P value text(Obesity class I)
Or beta1.07
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region9p21.1
Chromosome idchr9
Chromosome position28414341
Reported geneLINGO2
Mapped geneLINGO2
Upstream gene id
Downstream gene id
SNP gene ids158038
Upstream gene distance
Downstream gene distance
SNP risk allelers10968576-G
SNPsrs10968576
Merged0
SNP id current10968576
Contextintron_variant
Intergenic0
Allele frequency0.32
P value0.000005
Pvalue mlog5.30102999566398
P value text(EA, men)
Or beta0.02
%95 Ci[0.011-0.028] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region9p21.1
Chromosome idchr9
Chromosome position28414341
Reported geneLINGO2
Mapped geneLINGO2
Upstream gene id
Downstream gene id
SNP gene ids158038
Upstream gene distance
Downstream gene distance
SNP risk allelers10968576-G
SNPsrs10968576
Merged0
SNP id current10968576
Contextintron_variant
Intergenic0
Allele frequency0.319
P value0.00000000001
Pvalue mlog11
P value text(EA, women)
Or beta0.029
%95 Ci[0.02-0.037] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region9p21.1
Chromosome idchr9
Chromosome position28414341
Reported geneLINGO2
Mapped geneLINGO2
Upstream gene id
Downstream gene id
SNP gene ids158038
Upstream gene distance
Downstream gene distance
SNP risk allelers10968576-G
SNPsrs10968576
Merged0
SNP id current10968576
Contextintron_variant
Intergenic0
Allele frequency0.32
P value0.00000000000007
Pvalue mlog13.1549019599857
P value text(EA)
Or beta0.025
%95 Ci[0.018-0.031] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783
PubMed ID25673413
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673413
StudyGenetic studies of body mass index yield new insights for obesity biology.
Disease/TraitBody mass index
Initial sampleup to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
Replication sampleup to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828
Region9p21.1
Chromosome idchr9
Chromosome position28414341
Reported geneLINGO2
Mapped geneLINGO2
Upstream gene id
Downstream gene id
SNP gene ids158038
Upstream gene distance
Downstream gene distance
SNP risk allelers10968576-G
SNPsrs10968576
Merged0
SNP id current10968576
Contextintron_variant
Intergenic0
Allele frequency0.315
P value0.00000000000002
Pvalue mlog13.698970004336
P value text
Or beta0.025
%95 Ci[0.018-0.031] kg/m2 increase
PlatformAffymetrix, Illumina [2550021]
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002783