SNP Detail For rs10956445
1.Mapping Information
Human SNP ID rs10956445
Human chromosome chr8
Human SNP position 128775730
Pig chromosome chr4
Pig SNP position 11885851
2.Annotation Information
PubMed ID24709693
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/24709693
StudyGenome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
Disease/TraitResponse to methotrexate in juvenile idiopathic arthritis
Initial sample694 European ancestry child cases
Replication sampleNA
Region8q24.21
Chromosome idchr8
Chromosome position128775730
Reported geneADCY8, PVT1
Mapped geneLINC00824 - LOC105375756
Upstream gene id101927774
Downstream gene id105375756
SNP gene ids
Upstream gene distance211051
Downstream gene distance24226
SNP risk allelers10956445-C
SNPsrs10956445
Merged0
SNP id current10956445
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.0000005
Pvalue mlog6.30102999566398
P value text(AJC)
Or beta2.73
%95 Ci[1.67-3.79] unit decrease
PlatformIllumina [586062]
CNVN
Mapped traitresponse to methotrexate, chronic childhood arthritis
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0031427, http://www.ebi.ac.uk/efo/EFO_0002609
Study accessionGCST002408