SNP Detail For rs10930597
1.Mapping Information
Human SNP ID rs10930597
Human chromosome chr2
Human SNP position 173462117
Pig chromosome chr15
Pig SNP position 88858405
2.Annotation Information
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (high sodium and potassium intervention)
Initial sample1,836 Han Chinese ancestry individuals
Replication sample654 Han Chinese ancestry individuals
Region2q31.1
Chromosome idchr2
Chromosome position173462117
Reported geneCDCA7
Mapped geneLOC105373744 - LOC643997
Upstream gene id105373744
Downstream gene id643997
SNP gene ids
Upstream gene distance15338
Downstream gene distance23542
SNP risk allelers10930597-T
SNPsrs10930597
Merged0
SNP id current10930597
Contextintergenic_variant
Intergenic1
Allele frequency0.05
P value0.00000004
Pvalue mlog7.39794000867203
P value text(DBP, during intervention)
Or beta3.2
%95 Ci[2.06-4.34] mmHg decrease
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitdiastolic blood pressure, response to high sodium diet, response to dietary potassium supplementation
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336, http://www.ebi.ac.uk/efo/EFO_0005401, http://www.ebi.ac.uk/efo/EFO_0005403
Study accessionGCST002252
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (high sodium and potassium intervention)
Initial sample1,836 Han Chinese ancestry individuals
Replication sample654 Han Chinese ancestry individuals
Region2q31.1
Chromosome idchr2
Chromosome position173462117
Reported geneCDCA7
Mapped geneLOC105373744 - LOC643997
Upstream gene id105373744
Downstream gene id643997
SNP gene ids
Upstream gene distance15338
Downstream gene distance23542
SNP risk allelers10930597-T
SNPsrs10930597
Merged0
SNP id current10930597
Contextintergenic_variant
Intergenic1
Allele frequency0.05
P value0.00000001
Pvalue mlog8
P value text(MAP, during intervention)
Or beta3.48
%95 Ci[2.28-4.68] mmHg decrease
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitmean arterial pressure, response to high sodium diet, response to dietary potassium supplementation
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006340, http://www.ebi.ac.uk/efo/EFO_0005401, http://www.ebi.ac.uk/efo/EFO_0005403
Study accessionGCST002252
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (high sodium and potassium intervention)
Initial sample1,836 Han Chinese ancestry individuals
Replication sample654 Han Chinese ancestry individuals
Region2q31.1
Chromosome idchr2
Chromosome position173462117
Reported geneCDCA7
Mapped geneLOC105373744 - LOC643997
Upstream gene id105373744
Downstream gene id643997
SNP gene ids
Upstream gene distance15338
Downstream gene distance23542
SNP risk allelers10930597-T
SNPsrs10930597
Merged0
SNP id current10930597
Contextintergenic_variant
Intergenic1
Allele frequency0.05
P value0.000006
Pvalue mlog5.22184874961635
P value text(SBP, during intervention)
Or beta3.99
%95 Ci[2.27-5.71] mmHg decrease
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitsystolic blood pressure, response to high sodium diet, response to dietary potassium supplementation
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006335, http://www.ebi.ac.uk/efo/EFO_0005401, http://www.ebi.ac.uk/efo/EFO_0005403
Study accessionGCST002252
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (low sodium intervention)
Initial sample1,850 Han Chinese ancestry individuals
Replication sample660 Han Chinese ancestry individuals
Region2q31.1
Chromosome idchr2
Chromosome position173462117
Reported geneCDCA7
Mapped geneLOC105373744 - LOC643997
Upstream gene id105373744
Downstream gene id643997
SNP gene ids
Upstream gene distance15338
Downstream gene distance23542
SNP risk allelers10930597-T
SNPsrs10930597
Merged0
SNP id current10930597
Contextintergenic_variant
Intergenic1
Allele frequency0.05
P value0.0000005
Pvalue mlog6.30102999566398
P value text(DBP, during intervention)
Or beta3.11
%95 Ci[1.89-4.33] mmHg decrease
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitdiastolic blood pressure, response to low sodium diet
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336, http://www.ebi.ac.uk/efo/EFO_0005402
Study accessionGCST002250
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (low sodium intervention)
Initial sample1,850 Han Chinese ancestry individuals
Replication sample660 Han Chinese ancestry individuals
Region2q31.1
Chromosome idchr2
Chromosome position173462117
Reported geneCDCA7
Mapped geneLOC105373744 - LOC643997
Upstream gene id105373744
Downstream gene id643997
SNP gene ids
Upstream gene distance15338
Downstream gene distance23542
SNP risk allelers10930597-T
SNPsrs10930597
Merged0
SNP id current10930597
Contextintergenic_variant
Intergenic1
Allele frequency0.05
P value0.00000004
Pvalue mlog7.39794000867203
P value text(MAP, during intervention)
Or beta3.37
%95 Ci[2.17-4.57] mmHg decrease
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitmean arterial pressure, response to low sodium diet
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006340, http://www.ebi.ac.uk/efo/EFO_0005402
Study accessionGCST002250
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (low sodium intervention)
Initial sample1,850 Han Chinese ancestry individuals
Replication sample660 Han Chinese ancestry individuals
Region2q31.1
Chromosome idchr2
Chromosome position173462117
Reported geneCDCA7
Mapped geneLOC105373744 - LOC643997
Upstream gene id105373744
Downstream gene id643997
SNP gene ids
Upstream gene distance15338
Downstream gene distance23542
SNP risk allelers10930597-T
SNPsrs10930597
Merged0
SNP id current10930597
Contextintergenic_variant
Intergenic1
Allele frequency0.05
P value0.000007
Pvalue mlog5.15490195998574
P value text(SBP, during intervention)
Or beta3.72
%95 Ci[2.09-5.35] mmHg decrease
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitsystolic blood pressure, response to low sodium diet
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006335, http://www.ebi.ac.uk/efo/EFO_0005402
Study accessionGCST002250