Human SNP ID | rs10830963 |
---|---|
Human chromosome | chr11 |
Human SNP position | 92975544 |
Pig chromosome | chr9 |
Pig SNP position | 28805774 |
PubMed ID | 19060907 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060907 |
Study | Variants in MTNR1B influence fasting glucose levels. |
Disease/Trait | Fasting plasma glucose |
Initial sample | 35,812 European ancestry individuals |
Replication sample | NA |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-G |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.28 |
P value | 3E-50 |
Pvalue mlog | 49.5228787452803 |
P value text | |
Or beta | 0.07 |
%95 Ci | [0.06-0.08] mmol/l increase |
Platform | Affymetrix, Illumina, Perlegen [up to 2557249] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST000276 |
PubMed ID | 22286219 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22286219 |
Study | Genome-wide association study identifies multiple loci influencing human serum metabolite levels. |
Disease/Trait | Metabolite levels |
Initial sample | 8,330 European ancestry individuals |
Replication sample | NA |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-? |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000000003 |
Pvalue mlog | 10.5228787452803 |
P value text | (Glc) |
Or beta | 0.14 |
%95 Ci | [0.1-0.18] unit increase |
Platform | Illumina [~ 7700000] (imputed) |
CNV | N |
Mapped trait | metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004725 |
Study accession | GCST001391 |
PubMed ID | 22508271 |
Journal | Genet Epidemiol |
Link | www.ncbi.nlm.nih.gov/pubmed/22508271 |
Study | Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). |
Disease/Trait | Fasting plasma glucose |
Initial sample | 2,349 European ancestry individuals, 664 Chinese ancestry individuals, 1,366 African American individuals, 1,171 Hispanic individuals |
Replication sample | NA |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-G |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.27 |
P value | 0.000000000001 |
Pvalue mlog | 12 |
P value text | (Fasting glucose) |
Or beta | 1.38 |
%95 Ci | [1.01-1.75] mg/dL increase |
Platform | Affymetrix [NR] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST001486 |
PubMed ID | 20081858 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20081858 |
Study | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. |
Disease/Trait | Fasting glucose-related traits |
Initial sample | up to 46,186 European ancestry individuals |
Replication sample | up to 76,558 European ancestry individuals |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-G |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3 |
P value | 6E-175 |
Pvalue mlog | 174.221848749616 |
P value text | (FPG) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST000568 |
PubMed ID | 20081858 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20081858 |
Study | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. |
Disease/Trait | Fasting glucose-related traits |
Initial sample | up to 46,186 European ancestry individuals |
Replication sample | up to 76,558 European ancestry individuals |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-G |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3 |
P value | 3E-43 |
Pvalue mlog | 42.5228787452803 |
P value text | (HOMA-B) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | HOMA-B |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004469 |
Study accession | GCST000568 |
PubMed ID | 22581228 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22581228 |
Study | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
Disease/Trait | Fasting glucose-related traits (interaction with BMI) |
Initial sample | Up to 58,074 European ancestry individuals |
Replication sample | Up tp 38,422 European ancestry individuals |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-? |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 4E-105 |
Pvalue mlog | 104.397940008672 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2400000] (imputed) |
CNV | N |
Mapped trait | body mass index, fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340, http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST001527 |
PubMed ID | 24509480 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24509480 |
Study | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. |
Disease/Trait | Type 2 diabetes |
Initial sample | 12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance |
Replication sample | 21,491 European ancestry cases, 55,647 European ancestry controls |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-G |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.27 |
P value | 0.0000002 |
Pvalue mlog | 6.69897000433601 |
P value text | |
Or beta | 1.11 |
%95 Ci | [1.06-1.16] |
Platform | Affymetrix, Illumina [2500000] (imputed) |
CNV | N |
Mapped trait | type II diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001360 |
Study accession | GCST002352 |
PubMed ID | 23251661 |
Journal | PLoS One |
Link | www.ncbi.nlm.nih.gov/pubmed/23251661 |
Study | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
Disease/Trait | Obesity-related traits |
Initial sample | 815 Hispanic children from 263 families |
Replication sample | NA |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B, LOC642791 |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-G |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.205 |
P value | 0.00000004 |
Pvalue mlog | 7.39794000867203 |
P value text | (GLU ) |
Or beta | 0.05 |
%95 Ci | [NR] mg/dL increase |
Platform | Illumina [899892] |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST001762 |
PubMed ID | 25524916 |
Journal | Diabetes |
Link | www.ncbi.nlm.nih.gov/pubmed/25524916 |
Study | Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. |
Disease/Trait | Glucose homeostasis traits |
Initial sample | up to 4,176 Mexican American individuals |
Replication sample | NA |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | FAT3, MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-? |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | |
P value | 0.000000000005 |
Pvalue mlog | 11.3010299956639 |
P value text | (AIRg) |
Or beta | 2.76 |
%95 Ci | [1.88-3.64] unit decrease |
Platform | Illumina [693128] |
CNV | N |
Mapped trait | glucose homeostasis measurement, acute insulin response measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006896, http://www.ebi.ac.uk/efo/EFO_0006831 |
Study accession | GCST002726 |
PubMed ID | 25524916 |
Journal | Diabetes |
Link | www.ncbi.nlm.nih.gov/pubmed/25524916 |
Study | Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. |
Disease/Trait | Glucose homeostasis traits |
Initial sample | up to 4,176 Mexican American individuals |
Replication sample | NA |
Region | 11q14.3 |
Chromosome id | chr11 |
Chromosome position | 92975544 |
Reported gene | MTNR1B |
Mapped gene | MTNR1B |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4544 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10830963-? |
SNPs | rs10830963 |
Merged | 0 |
SNP id current | 10830963 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | |
P value | 0.00000000001 |
Pvalue mlog | 11 |
P value text | (DI) |
Or beta | 3.4 |
%95 Ci | [2.4-4.4] unit decrease |
Platform | Illumina [693128] |
CNV | N |
Mapped trait | disposition index measurement, glucose homeostasis measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0006832, http://www.ebi.ac.uk/efo/EFO_0006896 |
Study accession | GCST002726 |