SNP Detail For rs10830963
1.Mapping Information
Human SNP ID rs10830963
Human chromosome chr11
Human SNP position 92975544
Pig chromosome chr9
Pig SNP position 28805774
2.Annotation Information
PubMed ID19060907
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19060907
StudyVariants in MTNR1B influence fasting glucose levels.
Disease/TraitFasting plasma glucose
Initial sample35,812 European ancestry individuals
Replication sampleNA
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-G
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency0.28
P value3E-50
Pvalue mlog49.5228787452803
P value text
Or beta0.07
%95 Ci[0.06-0.08] mmol/l increase
PlatformAffymetrix, Illumina, Perlegen [up to 2557249] (imputed)
CNVN
Mapped traitfasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST000276
PubMed ID22286219
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22286219
StudyGenome-wide association study identifies multiple loci influencing human serum metabolite levels.
Disease/TraitMetabolite levels
Initial sample8,330 European ancestry individuals
Replication sampleNA
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-?
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.00000000003
Pvalue mlog10.5228787452803
P value text(Glc)
Or beta0.14
%95 Ci[0.1-0.18] unit increase
PlatformIllumina [~ 7700000] (imputed)
CNVN
Mapped traitmetabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004725
Study accessionGCST001391
PubMed ID22508271
JournalGenet Epidemiol
Linkwww.ncbi.nlm.nih.gov/pubmed/22508271
StudyFasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).
Disease/TraitFasting plasma glucose
Initial sample2,349 European ancestry individuals, 664 Chinese ancestry individuals, 1,366 African American individuals, 1,171 Hispanic individuals
Replication sampleNA
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-G
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency0.27
P value0.000000000001
Pvalue mlog12
P value text(Fasting glucose)
Or beta1.38
%95 Ci[1.01-1.75] mg/dL increase
PlatformAffymetrix [NR] (imputed)
CNVN
Mapped traitfasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST001486
PubMed ID20081858
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20081858
StudyNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Disease/TraitFasting glucose-related traits
Initial sampleup to 46,186 European ancestry individuals
Replication sampleup to 76,558 European ancestry individuals
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-G
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency0.3
P value6E-175
Pvalue mlog174.221848749616
P value text(FPG)
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitfasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST000568
PubMed ID20081858
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20081858
StudyNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Disease/TraitFasting glucose-related traits
Initial sampleup to 46,186 European ancestry individuals
Replication sampleup to 76,558 European ancestry individuals
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-G
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency0.3
P value3E-43
Pvalue mlog42.5228787452803
P value text(HOMA-B)
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitHOMA-B
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004469
Study accessionGCST000568
PubMed ID22581228
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22581228
StudyA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Disease/TraitFasting glucose-related traits (interaction with BMI)
Initial sampleUp to 58,074 European ancestry individuals
Replication sampleUp tp 38,422 European ancestry individuals
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-?
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequencyNR
P value4E-105
Pvalue mlog104.397940008672
P value text
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 2400000] (imputed)
CNVN
Mapped traitbody mass index, fasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340, http://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST001527
PubMed ID24509480
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24509480
StudyGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Disease/TraitType 2 diabetes
Initial sample12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance
Replication sample21,491 European ancestry cases, 55,647 European ancestry controls
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-G
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency0.27
P value0.0000002
Pvalue mlog6.69897000433601
P value text
Or beta1.11
%95 Ci[1.06-1.16]
PlatformAffymetrix, Illumina [2500000] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002352
PubMed ID23251661
JournalPLoS One
Linkwww.ncbi.nlm.nih.gov/pubmed/23251661
StudyNovel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Disease/TraitObesity-related traits
Initial sample815 Hispanic children from 263 families
Replication sampleNA
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B, LOC642791
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-G
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency0.205
P value0.00000004
Pvalue mlog7.39794000867203
P value text(GLU )
Or beta0.05
%95 Ci[NR] mg/dL increase
PlatformIllumina [899892]
CNVN
Mapped traitfasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST001762
PubMed ID25524916
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/25524916
StudyGenetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
Disease/TraitGlucose homeostasis traits
Initial sampleup to 4,176 Mexican American individuals
Replication sampleNA
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneFAT3, MTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-?
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency
P value0.000000000005
Pvalue mlog11.3010299956639
P value text(AIRg)
Or beta2.76
%95 Ci[1.88-3.64] unit decrease
PlatformIllumina [693128]
CNVN
Mapped traitglucose homeostasis measurement, acute insulin response measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006896, http://www.ebi.ac.uk/efo/EFO_0006831
Study accessionGCST002726
PubMed ID25524916
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/25524916
StudyGenetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
Disease/TraitGlucose homeostasis traits
Initial sampleup to 4,176 Mexican American individuals
Replication sampleNA
Region11q14.3
Chromosome idchr11
Chromosome position92975544
Reported geneMTNR1B
Mapped geneMTNR1B
Upstream gene id
Downstream gene id
SNP gene ids4544
Upstream gene distance
Downstream gene distance
SNP risk allelers10830963-?
SNPsrs10830963
Merged0
SNP id current10830963
Contextintron_variant
Intergenic0
Allele frequency
P value0.00000000001
Pvalue mlog11
P value text(DI)
Or beta3.4
%95 Ci[2.4-4.4] unit decrease
PlatformIllumina [693128]
CNVN
Mapped traitdisposition index measurement, glucose homeostasis measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006832, http://www.ebi.ac.uk/efo/EFO_0006896
Study accessionGCST002726