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SNP Detail For rs10821936
1.Mapping Information
| Human SNP ID | rs10821936 |
|---|---|
| Human chromosome | chr10 |
| Human SNP position | 61963818 |
| Pig chromosome | chr14 |
| Pig SNP position | 70469949 |
2.Annotation Information
| PubMed ID | 19684603 |
|---|---|
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/19684603 |
| Study | Germline genomic variants associated with childhood acute lymphoblastic leukemia. |
| Disease/Trait | Acute lymphoblastic leukemia (childhood) |
| Initial sample | 317 European ancestry cases, 17,958 European ancestry controls |
| Replication sample | NA |
| Region | 10q21.2 |
| Chromosome id | chr10 |
| Chromosome position | 61963818 |
| Reported gene | ARID5B |
| Mapped gene | ARID5B |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 84159 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs10821936-C |
| SNPs | rs10821936 |
| Merged | 0 |
| SNP id current | 10821936 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.34 |
| P value | 0.000000000000001 |
| Pvalue mlog | 15 |
| P value text | |
| Or beta | 1.91 |
| %95 Ci | [1.60-2.20] |
| Platform | Affymetrix [307944] |
| CNV | N |
| Mapped trait | acute lymphoblastic leukemia |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000220 |
| Study accession | GCST000464 |
| PubMed ID | 23512250 |
| Journal | J Natl Cancer Inst |
| Link | www.ncbi.nlm.nih.gov/pubmed/23512250 |
| Study | Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. |
| Disease/Trait | Acute lymphoblastic leukemia (childhood) |
| Initial sample | 972 European ancestry cases, 1,386 European ancestry controls, 89 African American cases, 1,363 African American controls, 305 Hispanic cases, 1,008 Hispanic controls |
| Replication sample | 574 European ancestry cases, 2,601 European ancestry controls, 128 African American cases, 1,075 African American controls, 143 Hispanic cases, 640 Hispanic controls |
| Region | 10q21.2 |
| Chromosome id | chr10 |
| Chromosome position | 61963818 |
| Reported gene | ARID5B |
| Mapped gene | ARID5B |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 84159 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs10821936-C |
| SNPs | rs10821936 |
| Merged | 0 |
| SNP id current | 10821936 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.33 |
| P value | 6E-46 |
| Pvalue mlog | 45.2218487496163 |
| P value text | |
| Or beta | 1.86 |
| %95 Ci | [1.71-2.03] |
| Platform | Affymetrix [709059] |
| CNV | N |
| Mapped trait | acute lymphoblastic leukemia |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000220 |
| Study accession | GCST001912 |
| PubMed ID | 22076464 |
| Journal | Leukemia |
| Link | www.ncbi.nlm.nih.gov/pubmed/22076464 |
| Study | Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. |
| Disease/Trait | Acute lymphoblastic leukemia (childhood) |
| Initial sample | 419 European ancestry ETV6-RUNX1 positive cases, 474 European ancestry controls |
| Replication sample | 951 European ancestry ETV6-RUNX1 positive cases, 326 European ancestry ETV6-RUNX1 negative cases, 3,061 European ancestry controls |
| Region | 10q21.2 |
| Chromosome id | chr10 |
| Chromosome position | 61963818 |
| Reported gene | ARID5B |
| Mapped gene | ARID5B |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 84159 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs10821936-C |
| SNPs | rs10821936 |
| Merged | 0 |
| SNP id current | 10821936 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.31 |
| P value | 0.00000000001 |
| Pvalue mlog | 11 |
| P value text | (ETV6-RUNX1 positive) |
| Or beta | 1.42 |
| %95 Ci | [1.29 - 1.58] |
| Platform | Affymetrix [355750] |
| CNV | N |
| Mapped trait | acute lymphoblastic leukemia |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000220 |
| Study accession | GCST001320 |
| PubMed ID | 22076464 |
| Journal | Leukemia |
| Link | www.ncbi.nlm.nih.gov/pubmed/22076464 |
| Study | Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. |
| Disease/Trait | Acute lymphoblastic leukemia (childhood) |
| Initial sample | 419 European ancestry ETV6-RUNX1 positive cases, 474 European ancestry controls |
| Replication sample | 951 European ancestry ETV6-RUNX1 positive cases, 326 European ancestry ETV6-RUNX1 negative cases, 3,061 European ancestry controls |
| Region | 10q21.2 |
| Chromosome id | chr10 |
| Chromosome position | 61963818 |
| Reported gene | ARID5B |
| Mapped gene | ARID5B |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 84159 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs10821936-C |
| SNPs | rs10821936 |
| Merged | 0 |
| SNP id current | 10821936 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.31 |
| P value | 0.000000000000004 |
| Pvalue mlog | 14.397940008672 |
| P value text | |
| Or beta | 1.46 |
| %95 Ci | [1.33 - 1.60] |
| Platform | Affymetrix [355750] |
| CNV | N |
| Mapped trait | acute lymphoblastic leukemia |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000220 |
| Study accession | GCST001320 |
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