SNP Detail For rs10811661
1.Mapping Information
Human SNP ID rs10811661
Human chromosome chr9
Human SNP position 22134095
Pig chromosome chr1
Pig SNP position 223789997
2.Annotation Information
PubMed ID19056611
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/19056611
StudyAdiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
Disease/TraitType 2 diabetes
Initial sample958 European ancestry obese cases, 955 European ancestry non-obese cases, 2,938 European ancestry controls
Replication sampleUp to 3,757 European ancestry cases, up to 5,346 European ancestry controls
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-?
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.0000007
Pvalue mlog6.15490195998574
P value text(non-obese)
Or beta1.26
%95 Ci[1.15-1.38]
PlatformAffymetrix [393453]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000277
PubMed ID17463249
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463249
StudyReplication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Disease/TraitType 2 diabetes
Initial sample1,924 European ancestry cases, 2,938 European ancestry controls
Replication sample3,757 European ancestry cases, 5,346 European ancestry controls
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2A, CDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-T
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequency0.83
P value0.000005
Pvalue mlog5.30102999566398
P value text
Or beta1.19
%95 Ci[1.11-1.28]
PlatformAffymetrix [393453]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000025
PubMed ID17463246
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463246
StudyGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Disease/TraitType 2 diabetes
Initial sample1,464 European ancestry cases, 1,467 European ancestry controls
Replication sample5,065 European ancestry cases, 5,785 European ancestry controls
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2A, CDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-T
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequency0.83
P value0.00000005
Pvalue mlog7.30102999566398
P value text
Or beta1.2
%95 Ci[1.12-1.28]
PlatformAffymetrix [386731]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000028
PubMed ID17463248
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463248
StudyA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Disease/TraitType 2 diabetes
Initial sample1,161 European ancestry cases, 1,174 European ancestry controls
Replication sample1,215 European ancestry cases, 1,258 European ancestry controls
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2A, CDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-T
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequency0.85
P value0.000000000000008
Pvalue mlog14.096910013008
P value text(DGI+FUSION+WTCCC)
Or beta1.2
%95 Ci[1.14-1.25]
PlatformIllumina [315635]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000024
PubMed ID22581228
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22581228
StudyA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Disease/TraitFasting glucose-related traits (interaction with BMI)
Initial sampleUp to 58,074 European ancestry individuals
Replication sampleUp tp 38,422 European ancestry individuals
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-?
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.000007
Pvalue mlog5.15490195998574
P value text
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 2400000] (imputed)
CNVN
Mapped traitbody mass index, fasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340, http://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST001527
PubMed ID25187374
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/25187374
StudyGenome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Disease/TraitFasting plasma glucose
Initial sample24,740 East Asian ancestry individuals
Replication sample21,345 East Asian ancestry individuals
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2A, CDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-?
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.000000000009
Pvalue mlog11.0457574905606
P value text
Or beta0.062
%95 Ci[0.044-0.080] unit increase
PlatformAffymetrix, Illumina [up to 2315813] (imputed)
CNVN
Mapped traitfasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST002586
PubMed ID23945395
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23945395
StudyGenome-wide association study identifies three novel loci for type 2 diabetes.
Disease/TraitType 2 diabetes
Initial sample5,976 Japanese ancestry cases, 20,829 Japanese ancestry controls
Replication sample24,416 East Asian ancestry cases, 13,985 East Asian ancestry controls
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2A, CDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-T
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequency0.55
P value0.000000000000000001
Pvalue mlog18
P value text
Or beta1.23
%95 Ci[1.18-1.29]
PlatformIllumina [6209637] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002128
PubMed ID24509480
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24509480
StudyGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Disease/TraitType 2 diabetes
Initial sample12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance
Replication sample21,491 European ancestry cases, 55,647 European ancestry controls
Region9p21.3
Chromosome idchr9
Chromosome position22134095
Reported geneCDKN2A, CDKN2B
Mapped geneCDKN2B-AS1 - DMRTA1
Upstream gene id100048912
Downstream gene id63951
SNP gene ids
Upstream gene distance12998
Downstream gene distance312746
SNP risk allelers10811661-T
SNPsrs10811661
Merged0
SNP id current10811661
Contextintergenic_variant
Intergenic1
Allele frequency0.82
P value1E-27
Pvalue mlog27
P value text
Or beta1.18
%95 Ci[1.13-1.24]
PlatformAffymetrix, Illumina [2500000] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002352