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SNP Detail For rs10519227
1.Mapping Information
| Human SNP ID | rs10519227 |
|---|---|
| Human chromosome | chr15 |
| Human SNP position | 49454167 |
| Pig chromosome | chr1 |
| Pig SNP position | 135859926 |
2.Annotation Information
| PubMed ID | 23408906 |
|---|---|
| Journal | PLoS Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/23408906 |
| Study | A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. |
| Disease/Trait | Thyroid hormone levels |
| Initial sample | up to 14,459 European ancestry females, up to 10,936 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males |
| Replication sample | NA |
| Region | 15q21.2 |
| Chromosome id | chr15 |
| Chromosome position | 49454167 |
| Reported gene | FGF7 |
| Mapped gene | FAM227B, FGF7 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 196951, 2252 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs10519227-A |
| SNPs | rs10519227 |
| Merged | 0 |
| SNP id current | 10519227 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.245 |
| P value | 0.00000000001 |
| Pvalue mlog | 11 |
| P value text | (TSH) |
| Or beta | 0.072 |
| %95 Ci | [0.05-0.094] unit decrease |
| Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
| CNV | N |
| Mapped trait | thyroid stimulating hormone measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004748 |
| Study accession | GCST001856 |
| PubMed ID | 23408906 |
| Journal | PLoS Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/23408906 |
| Study | A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. |
| Disease/Trait | Thyroid hormone levels |
| Initial sample | up to 14,459 European ancestry females, up to 10,936 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males |
| Replication sample | NA |
| Region | 15q21.2 |
| Chromosome id | chr15 |
| Chromosome position | 49454167 |
| Reported gene | FGF7 |
| Mapped gene | FAM227B, FGF7 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 196951, 2252 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs10519227-A |
| SNPs | rs10519227 |
| Merged | 0 |
| SNP id current | 10519227 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.245 |
| P value | 0.0000000006 |
| Pvalue mlog | 9.22184874961635 |
| P value text | (TSH - Males) |
| Or beta | 0.095 |
| %95 Ci | [0.066-0.124] unit decrease |
| Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
| CNV | N |
| Mapped trait | thyroid stimulating hormone measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004748 |
| Study accession | GCST001856 |
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Kunming Institute of Zoology, CAS
and Xi'an University of Technology ©2014-2017 All Rights Reserved.
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