SNP Detail For rs10508921
1.Mapping Information
Human SNP ID rs10508921
Human chromosome chr10
Human SNP position 50250948
Pig chromosome chr14
Pig SNP position 107939978
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region10q11.23
Chromosome idchr10
Chromosome position50250948
Reported geneASAH2
Mapped geneASAH2
Upstream gene id
Downstream gene id
SNP gene ids56624
Upstream gene distance
Downstream gene distance
SNP risk allelers10508921-T
SNPsrs10508921
Merged0
SNP id current10508921
Contextupstream_gene_variant
Intergenic0
Allele frequency0.13
P value0.0000009
Pvalue mlog6.04575749056067
P value text(AA-triglyceride response)
Or beta25.7
%95 Ci[15.47-35.93] mg/dL decrease
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, triglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST001859