SNP Detail For rs10504249
1.Mapping Information
Human SNP ID rs10504249
Human chromosome chr8
Human SNP position 57876522
Pig chromosome chr4
Pig SNP position 81756870
2.Annotation Information
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (low sodium intervention)
Initial sample1,850 Han Chinese ancestry individuals
Replication sample660 Han Chinese ancestry individuals
Region8q12.1
Chromosome idchr8
Chromosome position57876522
Reported geneFAM110B
Mapped geneLOC105375856
Upstream gene id
Downstream gene id
SNP gene ids105375856
Upstream gene distance
Downstream gene distance
SNP risk allelers10504249-G
SNPsrs10504249
Merged0
SNP id current10504249
Contextintergenic_variant
Intergenic0
Allele frequency0.02
P value0.0000001
Pvalue mlog7
P value text(DBP, response to intervention)
Or beta3.22
%95 Ci[2.02-4.42] mmHg increase
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitdiastolic blood pressure, response to low sodium diet
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336, http://www.ebi.ac.uk/efo/EFO_0005402
Study accessionGCST002250
PubMed ID24165912
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24165912
StudyGenome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
Disease/TraitBlood pressure measurement (low sodium intervention)
Initial sample1,850 Han Chinese ancestry individuals
Replication sample660 Han Chinese ancestry individuals
Region8q12.1
Chromosome idchr8
Chromosome position57876522
Reported geneFAM110B
Mapped geneLOC105375856
Upstream gene id
Downstream gene id
SNP gene ids105375856
Upstream gene distance
Downstream gene distance
SNP risk allelers10504249-G
SNPsrs10504249
Merged0
SNP id current10504249
Contextintergenic_variant
Intergenic0
Allele frequency0.02
P value0.0000004
Pvalue mlog6.39794000867203
P value text(MAP, response to intervention)
Or beta2.95
%95 Ci[1.81-4.09] mmHg increase
PlatformAffymetrix [2216774] (imputed)
CNVN
Mapped traitmean arterial pressure, response to low sodium diet
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006340, http://www.ebi.ac.uk/efo/EFO_0005402
Study accessionGCST002250