SNP Detail For rs10498633
1.Mapping Information
Human SNP ID rs10498633
Human chromosome chr14
Human SNP position 92460608
Pig chromosome chr7
Pig SNP position 120583330
2.Annotation Information
PubMed ID24162737
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24162737
StudyMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer__s disease.
Disease/TraitAlzheimer__s disease (late onset)
Initial sample17,008 European ancestry cases, 37,154 European ancestry controls
Replication sample8,572 European ancestry cases, 11,312 European ancestry controls
Region14q32.12
Chromosome idchr14
Chromosome position92460608
Reported geneSLC24A4, RIN3
Mapped geneSLC24A4
Upstream gene id
Downstream gene id
SNP gene ids123041
Upstream gene distance
Downstream gene distance
SNP risk allelers10498633-G
SNPsrs10498633
Merged0
SNP id current10498633
Contextintron_variant
Intergenic0
Allele frequency0.783
P value0.000000006
Pvalue mlog8.22184874961635
P value text
Or beta1.0989
%95 Ci[1.06-1.14]
PlatformIllumina [7055881] (imputed)
CNVN
Mapped traitAlzheimers disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249
Study accessionGCST002245
PubMed ID25778476
JournalMol Psychiatry
Linkwww.ncbi.nlm.nih.gov/pubmed/25778476
StudyA novel Alzheimer disease locus located near the gene encoding tau protein.
Disease/TraitAlzheimer__s disease in APOE e4- carriers
Initial sample7,184 cases, 26,968 controls
Replication sample718 European ancestry cases, 1,699 European ancestry controls
Region14q32.12
Chromosome idchr14
Chromosome position92460608
Reported geneSLC24A4
Mapped geneSLC24A4
Upstream gene id
Downstream gene id
SNP gene ids123041
Upstream gene distance
Downstream gene distance
SNP risk allelers10498633-G
SNPsrs10498633
Merged0
SNP id current10498633
Contextintron_variant
Intergenic0
Allele frequency0.78
P value0.0000004
Pvalue mlog6.39794000867203
P value text
Or beta1.1494253
%95 Ci[1.09-1.22]
PlatformNR [NR]
CNVN
Mapped traitAlzheimers disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249
Study accessionGCST002817